In a study published last Spring, (1) Paul Kroon and his team at the Institute for Food Research have shown that polyphenols in green tea and apples block a signalling growth molecule called VEGF (2) without causing side effects. This is the “magic” of holistic medicine via clinical nutrition, all of a food’s nutrients are stored in the right proportion by Nature, one consequence of which is its multiple pathways’ impact. Thanks to this synergistic mechanism, contrarily to synthetic patented drugs, side or toxic effects are bypassed. (3)
Another amazing aspect of this study is that the dosage for a therapeutic effect was not high. Using cells derived from human blood vessels, the researchers found that low concentrations of the polyphenols epigallocatechin gallate (EGCG) from green tea and procyanidin from apples was enough to stop the signalling function of VEGF.
Inhibition of VEGF signalling by dietary polyphenols has previously been shown in other studies, but this study provides the first evidence that polyphenols can directly interact with VEGF to block its signals, at the levels one would see in the blood stream after eating polyphenol rich Mediterranean diet and red wine.
REFERENCE AND COMMENT NOTES
(1). Christina W. A. Moyle et al, Potent inhibition of VEGFR-2 activation by tight binding of green tea epigallocatechin gallate and apple procyanidins to VEGF: Relevance to angiogenesis, Molecular Nutrition and Food Research, 59(3) 401-412. (Source)
(2). In the body, VEGF is a main driver of blood vessel formation in these cell types via a process called angiogenesis. Angiogenesis is crucial in cancer progression, as well as in the development of atherosclerotic plaques and plaque rupture which can cause heart attacks and stroke.
(3). In this perspective, the polyphenols activated another enzyme signalling system that generates nitric oxide in the blood, which helps widen the blood vessels and prevent damage. This was unexpected, as VEGF itself stimulates nitric oxide, and anti-cancer drugs that block VEGF tend to reduce nitric oxide, leading to an increased risk of hypertension.
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Disclaimer: Nothing in this education blog should be construed as medical advise.
Advanced Cancer Research Institute’s Director, Christian Joubert, has contributed in the coming and edification of a needed spiritual civilization by working as a professor of international public law in France and at Gonzaga Law School as well as in holistic medicine and other disciplines in different universities and institutes for most of his adult life. In association with his activities in clinical practice, organic agriculture, eco-development, community building, he has also actively participated via litigation and education in the legal protection of internationally recognized human rights, focusing on the protection of fundamental health rights and medical freedoms. He is presently working on a documentary and a book on Holistic Oncology, both of which have been designed to promote the necessary paradigm shift that will forever replace today's outdated, dogmatic, ideological and bankrupted conventional oncology model with progressive, evidence-based, sustainable and resilient holistic standards of care that are much more efficient, safe and cost-friendly than what persists in today's mainstream. See link on mission for more details.