In a study published last Spring, (1) Paul Kroon and his team at the Institute for Food Research have shown that polyphenols in green tea and apples block a signalling growth molecule called VEGF (2) without causing side effects. This is the “magic” of holistic medicine via clinical nutrition, all of a food’s nutrients are stored in the right proportion by Nature, one consequence of which is its multiple pathways’ impact. Thanks to this synergistic mechanism, contrarily to synthetic patented drugs, side or toxic effects are bypassed. (3)
Another amazing aspect of this study is that the dosage for a therapeutic effect was not high. Using cells derived from human blood vessels, the researchers found that low concentrations of the polyphenols epigallocatechin gallate (EGCG) from green tea and procyanidin from apples was enough to stop the signalling function of VEGF.
Inhibition of VEGF signalling by dietary polyphenols has previously been shown in other studies, but this study provides the first evidence that polyphenols can directly interact with VEGF to block its signals, at the levels one would see in the blood stream after eating polyphenol rich Mediterranean diet and red wine.
REFERENCE AND COMMENT NOTES
(1). Christina W. A. Moyle et al, Potent inhibition of VEGFR-2 activation by tight binding of green tea epigallocatechin gallate and apple procyanidins to VEGF: Relevance to angiogenesis, Molecular Nutrition and Food Research, 59(3) 401-412. (Source)
(2). In the body, VEGF is a main driver of blood vessel formation in these cell types via a process called angiogenesis. Angiogenesis is crucial in cancer progression, as well as in the development of atherosclerotic plaques and plaque rupture which can cause heart attacks and stroke.
(3). In this perspective, the polyphenols activated another enzyme signalling system that generates nitric oxide in the blood, which helps widen the blood vessels and prevent damage. This was unexpected, as VEGF itself stimulates nitric oxide, and anti-cancer drugs that block VEGF tend to reduce nitric oxide, leading to an increased risk of hypertension.
Copyright (c) 2016. Advanced Cancer Research Institute. All rights reserved.
Disclaimer: Nothing in this education blog should be construed as medical advise.
Professor Joubert teaches how to extend a healthy cancer-free Lifespan to 122 years thanks to safe, efficient and cost friendly breakthrough protocols. Working on a documentary and book that redefines Medicine in light of new discoveries, ancient wisdoms, innovative research and holistic science, he can be nonetheless available to coach patients back to homeostasis, wellbeing & Joie de Vivre. On occasion, Pr. Joubert can also coach health professionals to better protect their holistic practice when they must deviate from outdated and-or irrational mainstream “standards of care” in order to genuinely serve their patients, evidence-strong Science and internationally recognized human rights. For details, see the links called “Contact” and “Mission” (under the “About” link).