In a study published last Spring, (1) Paul Kroon and his team at the Institute for Food Research have shown that polyphenols in green tea and apples block a signalling growth molecule called VEGF (2) without causing side effects. This is the “magic” of holistic medicine via clinical nutrition, all of a food’s nutrients are stored in the right proportion by Nature, one consequence of which is its multiple pathways’ impact. Thanks to this synergistic mechanism, contrarily to synthetic patented drugs, side or toxic effects are bypassed. (3)
Another amazing aspect of this study is that the dosage for a therapeutic effect was not high. Using cells derived from human blood vessels, the researchers found that low concentrations of the polyphenols epigallocatechin gallate (EGCG) from green tea and procyanidin from apples was enough to stop the signalling function of VEGF.
Inhibition of VEGF signalling by dietary polyphenols has previously been shown in other studies, but this study provides the first evidence that polyphenols can directly interact with VEGF to block its signals, at the levels one would see in the blood stream after eating polyphenol rich Mediterranean diet and red wine.
REFERENCE AND COMMENT NOTES
(1). Christina W. A. Moyle et al, Potent inhibition of VEGFR-2 activation by tight binding of green tea epigallocatechin gallate and apple procyanidins to VEGF: Relevance to angiogenesis, Molecular Nutrition and Food Research, 59(3) 401-412. (Source)
(2). In the body, VEGF is a main driver of blood vessel formation in these cell types via a process called angiogenesis. Angiogenesis is crucial in cancer progression, as well as in the development of atherosclerotic plaques and plaque rupture which can cause heart attacks and stroke.
(3). In this perspective, the polyphenols activated another enzyme signalling system that generates nitric oxide in the blood, which helps widen the blood vessels and prevent damage. This was unexpected, as VEGF itself stimulates nitric oxide, and anti-cancer drugs that block VEGF tend to reduce nitric oxide, leading to an increased risk of hypertension.
Copyright (c) 2016. Advanced Cancer Research Institute. All rights reserved.
Disclaimer: Nothing in this education blog should be construed as medical advise.
Advanced Cancer Research Institute’s Founder, Christian Joubert has worked as a professor of public law and holistic medicine for most of his adult life, in association with his activities in organic agriculture. Christian’s has attained expertise in many fields, thanks to which he can help as many people as possible, including, but not limited to biogerontology, (ie, extending healthy human life-spans to over 120 years old), holistic oncology, traditional naturopathy (or what is also called “natural medicine”, coming from Hippocratic Tradition), French medicine, (classified by the W.H.O. as the number one out of in 191 countries, Cf. the link “about”), comparative public policy and international public law. Trained in conventional medicine, acupuncture, naturopathy, oenology, the social sciences and law in France, Christian has campaigned and litigated in Courts of law for multiple years in order to replace outdated medical standards of care with evidence-based holistic standards. His originality is based on being able to examine medicine and the health sciences with legal & forensic eyes, thanks to which he can distinguish the relevant data from the irrelevant. In addition, his broad knowledge relative to the health sciences, organic farming, ecology, eco-development, oenology (wine science), sociology, political science, the law and different cultures allows him to identify those key inter-connections that too often, most family members, medical doctors, professors of medicine and public health experts are not able to see or understand. To benefit in vivo from Christian’s trans-cultural, medical, legal and inter-disciplinary training and experience, click the Consult link in the top menu bar.