In a study published last Spring, (1) Paul Kroon and his team at the Institute for Food Research have shown that polyphenols in green tea and apples block a signalling growth molecule called VEGF (2) without causing side effects. This is the “magic” of holistic medicine via clinical nutrition, all of a food’s nutrients are stored in the right proportion by Nature, one consequence of which is its multiple pathways’ impact. Thanks to this synergistic mechanism, contrarily to synthetic patented drugs, side or toxic effects are bypassed. (3)
Another amazing aspect of this study is that the dosage for a therapeutic effect was not high. Using cells derived from human blood vessels, the researchers found that low concentrations of the polyphenols epigallocatechin gallate (EGCG) from green tea and procyanidin from apples was enough to stop the signalling function of VEGF.
Inhibition of VEGF signalling by dietary polyphenols has previously been shown in other studies, but this study provides the first evidence that polyphenols can directly interact with VEGF to block its signals, at the levels one would see in the blood stream after eating polyphenol rich Mediterranean diet and red wine.
REFERENCE AND COMMENT NOTES
(1). Christina W. A. Moyle et al, Potent inhibition of VEGFR-2 activation by tight binding of green tea epigallocatechin gallate and apple procyanidins to VEGF: Relevance to angiogenesis, Molecular Nutrition and Food Research, 59(3) 401-412. (Source)
(2). In the body, VEGF is a main driver of blood vessel formation in these cell types via a process called angiogenesis. Angiogenesis is crucial in cancer progression, as well as in the development of atherosclerotic plaques and plaque rupture which can cause heart attacks and stroke.
(3). In this perspective, the polyphenols activated another enzyme signalling system that generates nitric oxide in the blood, which helps widen the blood vessels and prevent damage. This was unexpected, as VEGF itself stimulates nitric oxide, and anti-cancer drugs that block VEGF tend to reduce nitric oxide, leading to an increased risk of hypertension.
Copyright (c) 2016. Advanced Cancer Research Institute. All rights reserved.
Disclaimer: Nothing in this education blog should be construed as medical advise.
Professor Joubert was trained in Conventional, Traditional Chinese and Naturopathic medicine and has been specializing in longevity science, biogerontology and holistic oncology for over twenty years. He is presently working on a new book on Holistic Medicine, Longevity and Cancer, whose content invokes the compelling evidence that supports the following assertion: humans have been genetically designed to live a happy and healthy lifespan to at least 120 years. On this age limit, both evolution-based Science (Cf the Hayflick's limit) and the Bible (Genesis 6:3) concur. The “Joie de Vivre” Vibe that can eradicate today’s chronic disease epidemics and un-necessary suffering is thus within reach. See link on mission for more details.