Conventional “early detection” is based on medical imagery, including, but not limited to Pep scans, mri, xrays, mammograms, biomarkers like psa and hpv pap smear tests and a few other diagnostic tools, most of which are not early and can be invasive, expensive and inaccurate. Worse, none of the mainstream early detesting and detection interventions look for circulatory cancer stem cells on enzymes secreted by tumor cells called nagalse.
Yet, these are the cells that are at the root of malignancies, in particular of metastases (Source) and those are the enzymes that hinder immune-surveillance.
Regarding breast cancer, by the time a tumor is seen on a mammogram, up to 8 years can have accumulated. Futhermore, these x-ray based machines have a 4 percent cancer risks with at least 20 percent false readings (false positive and false negative). (1)
Below are a few earlier detection tools the ACR Institute prefers, most of which can also be used as monitoring techniques to evaluate the response potential of a given treatment.
1 CIRCULATORY TUMOR AND STEM CELL TESTS
Evaluating the molecular biology of the tumor cell population and its CTC. (CTC – Circulating tumor cells) is an important part of cancer testing that is missed by most conventional oncologists. By far, the most important test is this one because tumor circulatory stem cells can shed from a 2mm tumor and these are the cells that are the engins of metastases, from which most cancer patients die. For an understanding of circulatory Tumor and cancer stem cells, see this Source. In the United States, the best place to order this test can be ordered at the Cell Search Link.
2. CHEMO-SENSITIVITY & GENOMIC TESTS (molecular cancer diagnostics)
Chemo-sensitivity and genomic testing are useful when the patient uses chemotherapeutic agents and even some supplements. These tools can help to individualized protocols thereby finding the most effective and safest pharmaceutical and neutraceutical interventions. (2) These tests can be ordered via the links below:
1. The Greek RGCC test has a 2 week turnaround time. It can cost $2700 – $3000 depending on the exchange rate and is not usually reimbursable by insurance.
3. Dr Nagourney in California proposes a smilar tests, but for more expensive, at around 4000 dollars. Furthermore, Dr Nagourney only tests the primary tumor and usually required a large biopsy.
This test has high accurate and tells the client where most of the cancers are located. This test is based on the discovery of a cancer-specific universal cancer marker called ENOX2, which is a growth-related protein that appears on the surface of cancer cell only and is then released into the blood stream. If the ENOX2 protein is found, the ONCOblot can then identify 27 different types of cancer as well as the organ of origin. These results give patients time and ability to have very targeted treatments. The ONCOblot test is so sensitive that it detects as few as 2 million cancer cells which is equivalent to 0.8mm or .03 inch, which is size of the period mark at the end of this sentence. It can be ordered via the link below. This test can be directly order via its producer in Germany.
4. CANCER PROFILE TEST
The Cancer Profile test is based on the premise that detectable biochemical changes occur in the human body during its transformation into a cancerous state. It is composed of 8 tests: HCG (human chorionic gonadotropin), tested under 3 different angles, serum chemiluminescence assay and immunoradiometric assay, and urine quantitative chemiluminescence assay; the PHI (phosphohexose isomerase enzyme); CEA (carcinoembryonic antigen); GGTP (gamma-glutamyltranspeptidase);TSH (thyroid-stimulating hormone); and DHEA-S (dehydroepiandrosterone sulfate). Dr. Schandl, the developer of this test, has observed marker elevations in patients as many as 10 to 12 years prior to diagnosis. Knowing that the developmental process of cancer takes 10 to12 years, one may be able to detect the very beginning of cancer, allowing plenty of time to make lifestyle adjustment corrections and take in key supplements and other holistic techniques in order to avoid carcinogenesis.
This test can be used not only for early detection, but also for clinical laboratory follow-up and monitoring disease reduction or progression. Consider the fact, testing for HCG alone can result in approximately 30% false negative results. The entire Cancer Profile may miss only 10-15% cancer positive patients. (2) This test can be ordered directly from the producer, located in Florida, US. (3)
5. THE NAGALESE BLOOD TEST
The Nagalase test is a simple blood test that measures the presence of the enzyme Nagalase. Nagalase is produced by cancer cells (and some viruses) and not by healthy cells. Any amount of Nagalase in the blood means that there are cancer cells that are multiplying and dividing. It has been shown that nagalase basically undermines the Immune System so that the macrophages that gobble up and dismantle cancer cells can no longer do their job. (4)
The strong point of this Nagalase test is that it is ultra sensitive. It can detect cancer when it is at the cellular stage instead of the tumor stage. It can take 5-10 years for a tumor to develop and be seen on an x-ray or in blood work. This Nagalase test significantly accelerates detection time.
This test can also be used for monitoring the effect of therapy of cancer and certain viral infections, including but not limited to HIV & Autism.
6. THERMOGRAPHY IN COMBINATION WITH ULTRASOUND AND COMPUTERIZED REGULATION ANALYSIS
Microcalcifications in breast tissue indicate an increased risk for the development of certain breast cancers. Studies have shown that abnormal thermal patterns represent a far more reliable risk factor than family history (Gautherie, 1995).
The combination thermography and ultrasound is safe and effective in detecting early breast cancer, years before what a mamograms ability to detect breast cancer and with a higher accuracy rate and lower toxicity. Even better, a new thermographic dynamic whole-body detection tool has been perfected for better results. The Institute’s holistic oncology workshop details this new technique. (5)
7. THE PHILIPINE’S NAVARRO URINE (HCG) TEST
Even though HCG is the pregnancy hormone, it can be used as a cancer marker because both carcinogenesis and pregnancy share the activation of this hormone. The Navarro test does not accurately report normals below 5.0mIU/mL. Most cancer patients have HCG levels between 1 and 5. The Navarro’s cut-off point is less than 1.0 and the sensitivity of the immunoradiometric assay (IRMA) is 0.03 mIU/mL. This is one of the cheapest exams in the market (under 60 dollars) and can be used as a cancer marker, even it’s not full proof. To order this test, see this Website.
The Navarro Medical Clinic has been performing the HCG test for cancer for many years and continues to offer this service under the direction of Dr. Efren Navarro. Dr. Efren Navarro, the son of the late Dr. Manuel D Navarro is a graduate of Doctor of Medicine from the University of Santo Thomas, School of Medicine and Surgery, Manila Philippines. He finished his residency in Pathology at Mercy Hospital Medical Center in Chicago. In 1994 he became a Hematopathology Fellow at the University of Illinois, Chicago. In 1996, he returned to the Philippines to continue the work of his famous oncologist father, Manuel Navarro, M.D.
Currently, many cancer patients take advantage of the diagnostic accuracy of the HCG test as an indicator of the effectiveness of their specific mode of therapy. Thousands of cancer survivors have used this test over the years to keep track of their treatment(s) success and check on the status of their remission. Patients follow a simple direction for preparing a dry extract from the urine sample. The powdery extract is mailed to the Navarro Medical Clinic where the HCG testing is performed.
8. FRANCE’S ONCOTEST
Relatively low-tech and inexpensive to perform, the French Oncotest from Dr Beljanski is a relatively low-tech and inexpensive to perform, the Oncotest methodology was first patented by Dr.Mirko Beljanski and then included in his 1983 work «Regulation of DNA Replication and Transcription» published by Karger.
So, when cancerous DNA was exposed to carcinogenic substances, it replicated rapidly, while non-cancerous DNA replicated only slightly. This could be shown experimentally by adding substances to cancerous DNA or normal DNA and measuring either the increase in growth of the DNA or light absorption of the materials, as the more unstable the DNA, the more light that it would absorb (hyperchromicity (see illustration on the right)). Once carcinogens had destabilized normal DNA to the point that it became permanently destabilized (had become cancerous DNA), further exposure to carcinogens would increase the destabilization, making the cancerous DNA unstable. In other words, cancers cells could become more aggressive and bizarre as they were exposed to more carcinogens.”
These observations resulted in Beljanski developing a test to screen substances for carcinogenicity, which he patented in the 70s as the “Oncotest.” Carcinogens resulted in the rapid replication of cancerous DNA, but affected normal DNA only slightly. Most importantly, the Oncotest revealed that a compound could show carcinogenic properties (by affecting DNA structure) without necessarily being a mutagen, which acts by altering DNA and protein sequences. The Oncotest was ultimately used to test hundreds of compounds for their effect on DNA stability and their potential to act as carcinogens. Relatively low-tech and inexpensive to perform, the Oncotest methodology was first patented by Dr.MirkoBeljanski and then included in his 1983 work «Regulation of DNA Replication and Transcription» published by Karger. (Source)
9. ANIMAL CANCER DETECTION SNIFFING
Of all animals, so far, the evidence shows that dogs are the best to detect early stage cancer in humans. Canine cancer detection is an approach to cancer screening that relies upon the olfactory ability of dogs to detect, in urine or in breath, very low concentrations of the alkanes and aromatic compounds generated by tumors. At the ACR Institute, we are working in getting at least one dog or cat that can be trained in this skill. For the details, see Source.
Among others, see the Institute’s workshops for many more early detection diagnostic tests. One that comes to mind is the French Oligoscan has been touted as a great diagnostic tool. But the Institute can’t form an opinioin not having experience with this biofeedback scan.
COMPLEMENTARY TESTS TO CHECK RELATED CANCER ISSUES
1. CRP TEST
C- Reactive Protein, (CRP) blood marker measuring inflammation, has long been thought of as a marker for cardiovascular disease, but updated research has shown us that it is a critical marker for cancer as well. Elevated CRP level is associated with a reduced survival rate with cancers because inflammation is one of the drivers of the malignancy process. CRP is now recognized as an inflammatory marker but it is also a cause of inflammation. CRP is a protein that is synthesized in the liver and is produced by the Immune Cells and fat cells. It is a very sensitive marker that indicates the levels of inflammation in the body. Inflammation is a precursor to the development of cancer. Think of inflammation as a slow burning fire that is fueled by too much omega 6s, bad diet, sugar intake, stress, toxins, and lack of sleep. As the inflammation rises it can initiate the initiation and progression of cancer.
2. 25-HYDROXY VITAMIN D TEST (25-hydroxycholecalciferol test)
The 25-hydroxy vitamin D test is the most accurate way to measure how much vitamin D is in your body. In the kidney, 25-hydroxy vitamin D changes into an active form of the vitamin. The active form of vitamin D helps control calcium and phosphate levels in the body. The normal range of vitamin D is measured as nanograms per milliliter (ng/mL). Many experts recommend a level between 20 and 40 ng/mL. Others recommend a level between 30 and 50 ng/mL. Cancer patients have a very low level of vitamin D. Unless there is a liver or kidney disease or the patient is taking certain drugs like phenytoin, phenobarbital, and rifampin, vitamin D deficiency can be corrected with sunlight, supplement, diet and other techniques. For more, see this Source.
3. MELATONIN PROFILE TEST
Sleeping correctly is essential in holistic cancer therapy. Furthermore, melatonin is one of the strongest antioxidants the body has. In Italy, a hospital abundantly uses melatonin to better control and reverse cancer. In this perspective, the Comprehensive Melatonin Profile is a convenient, non-invasive salivary hormone test that analyzes the circadian secretion patterns of melatonin. Using a complete light-dark cycle, this hormone test reveals abnormal levels of melatonin that relates to various physical and psychological symptoms as well as premature acceleration of the body´s aging process. Genova Diagnostics´ Comprehensive Melatonin Profile offers many distinct clinical advantages. This hormone test analyzes three saliva specimens taken at morning, noon, and midnight. This type of hormone testing allows for evaluation of melatonin activity of a complete light-dark cycle. It also measures salivary levels which correlate well with serum testing. This hormone test offers a safe, economical, and non-invasive way of assessing pineal function and melatonin secretion patterns
Melatonin is synthesized within the pineal gland from tryptophan during the dark phase of the day. With its unique ability to pass through all blood barriers in the body, melatonin acts as the central hub of physiological function. Once hormonal imbalances have been identified, results can be used to design and implement successful therapeutic programs, including timed application of bright light, removal of interfering factors, and melatonin administration. Melatonin imbalances have been associated with a wide array of health problems, including, but not limited to cancer, sleep disorders, depression, seasonal Affective Disorder (SAD), chronic progressive multiple sclerosis and menstrual irregularities. Melatonin also orchestrates the complex interactions between the mind, body, and environment while it influences most of the autonomic, hormonal, and behavioral functions of the human organism, including by advancing sleep time and duration, by modulate annual and circadian biorhythms (thereby reducing symptoms of jet-lag), by regulate the body temperature, cardiovascular function, immune function and female reproductive hormones.
Melatonin´s synthesis and secretion can be strongly influenced by day length, artificial illumination, electromagnetic energy, exercise, seasonal changes, impairment in methionine metabolism, and aging. Since synthesis and secretion are easily disrupted, accurate assessment of levels and circadian rhythm can be significant.
4. ORAL HYGIENE TESTS
As different cancer experts have shown (6), oral hygiene is needed for one’s immune system to function correctly. Thus mercury amalgams, root canals and other areas of infection need to be tested and corrected.
These are just some of the more popular and reliable detection and monitoring cancer tools. There are many others that the ACR Institute’s Cancer Diagnostic workshop details. See also the Institute’s video on this question.
Ch. J (ACR Institute Director)
PRECISION AND REFERENCE NOTES