Spontaneous Reversal of Cancers

Spontaneous cancer remission, also called spontaneous healing or spontaneous regression, is an unexpected improvement or cure from a cancer that usually progresses with the conventional allopathic oncology. In this perspective, the spontaneous regression and remission from cancer was defined by Everson and Cole in their 1966 book as:

“the partial or complete disappearance of a malignant tumour in the absence of all treatment, or in the presence of therapy which is considered inadequate to exert significant influence on neoplastic disease. .”  (1)

Like with the factors of bleu zones.

Text under construction

Frequency of spontaneous regression in cancer

Ths is the key issue.  In the mainstream litterature,  1 in 100,000 cancers where considered to be reversed. (2) On the other hand, in the Institute’s experience, it is more like 75,000 in 100,000 of cancer patients that can durably heal holistically, provided they dont get conventional oncology.

Because of public and legal pressure, most get poisoned by chemo and radio, hence the very low rate of cure.

Most cases are not well documented or the physician was not willing to publish, or simply because the patient ceased to attend a clinic any more.

It is likely that the frequency of spontaneous regression in small tumors has been drastically underrated. In a carefully designed study on mammography it was found that 22% of all breast cancer cases underwent spontaneous regression.[3]. 

Other cancers also have been know to spontaneously regress, in particular thyroid and prostate.

Causes

In many cases, available knowledge permits one to infer that hormonal influences probably were important. … In other cases, the protocols strongly suggest that an immune mechanism was responsible.[1]

Apoptosis (programmed cell death) and anti-angiogenesis processes are sometimes discussed as possible causes of spontaneous regression.

There are several case reports of spontaneous regressions from cancer occurring after a fever brought on by infection,[2][6] suggesting a possible causal connection. If this coincidence in time would be a causal connection, it should as well precipitate as prophylactic effect, i.e. feverish infections should lower the risk to develop cancer later. This could be confirmed by collecting epidemiological studies.[7] [8]

Discussion

Challis and Stam, even more at a loss, concluded in 1989, “In summary, we are left to conclude that, although a great number of interesting and unusual cases continue to be published annually, there is still little conclusive data that explains the occurrence of spontaneous regression.”[4]

Some Data

  • Rohdenburg (1918) summarized 185 spontaneous regressions[9]
  • Fauvet reported 202 cases between 1960–1964[10]
  • Boyd reported 98 cases in 1966[11]
  • Everson and Cole described 176 cases between 1900–1960[1][12]
  • Challis summarized 489 cases between 1900–1987[4]
  • O’Regan Brendan, Carlyle Hirschberg collected over 3,500 references from the medical literature[13]
  • Hobohm, in a meta-analysis, investigated about 1000 cases[2]
  • Turner, in a qualitative research study, conducted interviews with 20 patients with spontaneous remissions[14]
  • Gonzalas reported 50 cases.
  • Gerson also

 

References

  1. ^ Jump up to:
    a b c Everson T., Cole W. (1968) Spontaneous Regression of Cancer Philadelphia, JB Saunder & Co (Book)
  2. ^ Jump up to:
    a b c Hobohm U (October 2001). “Fever and cancer in perspective”. Cancer Immunol. Immunother. 50 (8): 391–6. doi:10.1007/s002620100216. PMID 11726133.
  3. Jump up
    ^
    Per-Henrik Zahl; Jan Mæhlen; H. Gilbert Welch (Nov 24, 2008). “The Natural History of Invasive Breast Cancers Detected by Screening Mammography”. Arch. Intern. Med. 168 (21): 2311–6. doi:10.1001/archinte.168.21.2311. PMID 19029493.
  4. ^ Jump up to:
    a b Challis GB, Stam HJ (1990). “The spontaneous regression of cancer. A review of cases from 1900 to 1987″. Acta Oncol. 29 (5): 545–50. doi:10.3109/02841869009090048. PMID 2206563.
  5. Jump up
    ^
    Robert A.Weinberg: The Biology of Cancer, Garland Science 2007
  6. Jump up
    ^
    Hobohm U (February 2005). “Fever therapy revisited”. Br. J. Cancer. 92 (3): 421–5. doi:10.1038/sj.bjc.6602386. PMC 2362074. PMID 15700041.
  7. Jump up
    ^
    Hobohm U, Stanford JL, Grange JM (2008). “Pathogen-associated molecular pattern in cancer immunotherapy”. Crit. Rev. Immunol. 28 (2): 95–107. doi:10.1615/critrevimmunol.v28.i2.10. PMID 18540826.
  8. Jump up
    ^
    Maletzki C, Linnebacher M, Savai R, Hobohm U (2013). “Mistletoe lectin has a shiga toxin-like structure and should be combined with other Toll-like receptor ligands in cancer therapy” (PDF). Canc. Immunol. Immunother. 62 (2): 1283–1292. doi:10.1007/s00262-013-1455-1. PMID 23832140.
  9. Jump up
    ^
    Rohdenburg (1918). “Fluctuations in the growth energy of tumors in man, with esspecial reference to spontaneous recession”. J Cancer Res. 3: 193–225.
  10. Jump up
    ^
    FAUVET J, ROUJEAU J, PIET R (June 1964). “[SPONTANEOUS CANCER CURES AND REGRESSIONS]”. Rev Prat (in French). 14: 2177–80. PMID 14157391.
  11. Jump up
    ^
    Boyd W: The spontaneous regression of cancer. Charles Thomas, Publ., Springfield Ill. 1966 (Book)
  12. Jump up
    ^
    Cole WH (November 1976). “Spontaneous regression of cancer and the importance of finding its cause”. Natl Cancer Inst Monogr. 44: 5–9. PMID 799760.
  13. Jump up
    ^
    O’Regan, Brendan; Hirschberg, Carlyle (1993). Spontaneous Remission. An Annotated Bibliography. Sausalito, California: Institute of Noetic Sciences. ISBN 0-943951-17-8.
  14. Jump up
    ^
    Turner, Kelly Ann (2010). Spontaneous Remission of Cancer: Theories from Healers, Physicians, and Cancer Survivors. Berkeley: UC Berkeley Electronic Theses and Dissertations.

Further reading[edit]

External links[edit]

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The disappearance of cancer without a satisfactory scientific explanation is rarely encountered by physicians. The process is typically called “spontaneous regression” or “spontaneous remission,” and a considerable body of literature confirms that cancer and benign tumors do indeed “disappear” and, in exceptional cases, patients are cured of the disease — in which case the phrase “miraculous healing” is sometimes invoked.

The patron saint of cancer patients is St Peregrine, OSM (1265-1345), a 14th century priest whose cancerous leg became ulcerated and festered for years and was, according to Christian legend, healed by Divine intervention the night before he was scheduled to undergo amputation.1,2 Case reports like this are today well within the framework of unexplained phenomena that fits the general rubric of “spontaneous regression.”3

Discounting these unique events may be the easiest course of action but it is unscientific, as medical historian and hematologist (and atheist) Dr Jocalyn Duffin noted in an analysis of Vatican archives in her book, Medical Miracles: Doctors, Saints, and Healing in the Modern World.4 Her interest in this subject started when Dr Duffin was sent pathology slides for interpretation from the Vatican regarding a patient diagnosed with acute myeloblastic leukemia who failed all available treatment. The source of the slides was unknown to her at first, though more than 30 years later the patient is alive after the cancer disappeared.4,5

Critical analysis of cases of spontaneous regression by sober and scientific observers dates back more than a century to physicians like Dr William Coley, Dr G.L. Rohdenburg in 1918, landmark studies by Drs J.J. and J.H. Morton in 1953, and the widely cited review by Drs T. Everson and W. Cole in 1956.6-8 The latter study defined the modern version of spontaneous regression of cancer as: “the partial or complete disappearance of a malignant tumor in the absence of all treatment, or in the presence of therapy which is considered inadequate to exert a significant influence on neoplastic disease.”

Medical literature is now filled with observations of biopsy-confirmed malignancies with computerized tomography (CT) scans or magnetic resonance images (MRIs) showing widespread disease that spontaneously regresses, which encompasses nearly every cancer type and histology.

Type of Cancers that went into Reversal Gear

Examples include: acute myelocytic leukemia, chronic lymphocytic leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma, breast cancer, non–small cell and small cell lung cancer, testicular cancer, prostate cancer, cervical cancer, hepatocellular cancer, colon cancer, Merkel cell carcinoma, sarcoma, melanoma, neuroblastoma, astrocytoma, and renal cell carcinoma.9-26

Mechanisms

The mechanisms most-often implicated in driving the spontaneous regression of cancer are thought to be mediated by immune system activation (or reactivation). Sometimes the driving force is an acute intercurrent bacterial or viral infection. Initiated by the work of Dr Lloyd Old, the founder of modern cancer immunology, the US Food and Drug Administration (FDA) in 1990 approved the first bacterial immunotherapy, Bacillus Calmette-Guerin (BCG), for in situ bladder cancer. More recently the FDA approved T-Vec [talimogene laherparepvec], a viral vaccine used to evoke an immune response in patients with advanced melanoma.27-29

The development of other viral and bacterial vectors is an active area of new drug development, with further success anticipated.30,31 The recent approval of checkpoint inhibitors against an array of cancers and chimeric antigen receptor (CAR)-T cell therapy are testimonies to the power of the immune system, when it awakes from its slumber, to simulate a process historically regarded as “miraculous.”32,33

The immuno-editing theory proposed by Drs Robert Schreiber, Mark Smyth, and Lloyd Old has helped to refine medical understanding of spontaneous regression, which may be seen as the interplay of cancer undergoing incomplete elimination, equilibrium, and escape.34 Under ideal conditions the innate and adaptive elements of the immune system work in concert to eliminate the cancer (often imperfectly) with regulatory (CD4+) and cytotoxic (CD8+) T cells, dendritic (or antigen presenting cells), natural killer (NK) cells, and macrophages along with a host of immune-activating secreted proteins such as interferon gamma, interleukin 12, and tumor necrosis factor (TNF) all working in harmony. Spontaneous regression may in some cases be a manifestation of this dynamic process, and immunoediting fits well into observations that most cancers that undergo spontaneous regression recur, sometimes years later.

Another example of this phenomenon can be seen with the so-called abscopal (or out-of-field) effects of radiation therapy, which causes the immune system to mount a systemic response to distant metastases.35

.

References

  1. Pack GT. St. Peregrine, O.S.M.–the patron saint of cancer patients. CA Cancer J Clin. 1967;17(4):181-2.
  2. Jackson R. Saint Peregrine, O.S.M.–the patron saint of cancer patients. Can Med Assoc J. 1974; 111(8):824-7.
  3. Krone B, Kölmel KF, Grange JM. The biography of immune system and the control of cancer: from St Peregrine to contemporary vaccination strategies. BMC Cancer. 2014;14:595. doi: 10.1186/1471-2407-14-595
  4. Duffin J. Medical Miracles: Doctors, Saints, and Healing in the Modern World. Oxford: 2008.
  5. Pukel C. Immunotherapy in the twentieth century: William Coley and Lloyd J. Old. Cancer Therapy Advisor website. Published March 15, 2017.
  6. Rohdenburg GL. Fluctuations of the growth energy of malignant tumors in man with especial reference to spontaneous reference. Cancer Res. 1918;(3)2:193-225.
  7. Morton JJ, Morton JH. Cancer as a chronic disease. Ann Surg. 1953;(137):683.
  8. Everson TC, Cole WH. Spontaneous regression of cancer: preliminary report. Ann Surg. 1956;144(3):366-80.
  9. Barrett R, Morash B, Roback D, et al. FISH identifies a KAT6A/CREBBP fusion caused by a cryptic insertional t(8;16) in a case of a spontaneously remitting congenital acute myeloid leukemia with normal karyotype. Pediatr Blood Cancer. 2017;64(8). doi: 10.1002/pbc.26450
  10. D’Arena G, Guariglia R, Pietrantuono G, et al. More on spontaneous regression of chronic lymphocytic leukemia: two new cases and potential role of lamivudine in a further patient with advanced disease and hepatitis B virus infection. Leuk Lymphoma. 2014:55(8):1955-7. doi: 10.3109/10428194.2013.858151
  11. Udupa K, Philip A, Rajendranath R, Sagar T, Majhi U. Spontaneous regression of primary progressive Hodgkin’s lymphoma in a pediatric patient: a case report and review of literature. Hematol Oncol Stem Cell Ther. 2013;6(3-4):112-6. doi: 10.1016/j.hermonc.2013.06.004
  12. Takahashi T, Ikejiri F, Takami S, et al. Spontaneous regression of intravascular large b-cell lymphoma and apoptosis of lymphoma cells: a case report. J Clin Exp Hematop. 2015;55(3):151-6. doi: 10.3960/jstrt.55.151
  13. Ito E, Nakano S, Otsuka M, et al. Spontaneous breast cancer remission: a case report. Int J Surg Case Rep. 2016;25:132-6. doi: 10.1016/j.ijscr.2016.06.017
  14. Nakamura Y, Noguchi Y, Satoh, E et al. Spontaneous remission of a non-small cell lung cancer possibly caused by anti-NY-ESO-1 immunity. Lung Cancer. 2009:65(1):119-22. doi: 10.1016/j.lungcan.2008.12.020
  15. Kitai H, Sakakibara-Konishi J, Oizumi S, et al. Spontaneous regression of small cell lung cancer combined with cancer associated retinopathy. Lung Cancer. 2015;87(1):73-6. doi: 10.1016/j.lung ca.2014.10.015
  16. Balzer BL, Ulbright TM. Spontaneous regression of testicular germ cell tumors: an analysis of 42 cases. Am J Surg Path. 2006;30(7):858-65.
  17. Lee T, Guo Y, Vij S, Bansal R, Wong NC, Shayegan B. Case: spontaneous regression of post-radical prostatectomy prostate-specific antigen elevation without adjuvant therapy in a patient with lymph node metastasis. Can Urol Assoc J. 2017;11(7):E315-7. http://dx.doi.org/10.5489/cuaj.4324
  18. Katano A, Takenaka R, Okuma K, Yamashita H, Nakagawa K. Repeated episodes of spontaneous regression/progression of cervical adenocarcinoma after adjuvant chemoradiation therapy: a case report. J Med Case Rep. 2015;9:114.
  19. Parks AL, McWhirter RM, Evason K, Kelley RK. Cases of spontaneous tumor regression in hepatobiliary cancers: implications for immunotherapy? J Gastrointest Cancer. 2015;46(2):161-5. doi: 10.1007/s12029-015-9690-7
  20. Chida K, Nakanishi K, Shomura H, et al. Spontaneous regression of transverse colon cancer: a case report. Surg Case Rep. 2017;3:65. doi: 10.1186/s40792-017-0341-z
  21. Pang C, Sharma D, Sankar T. Spontaneous regression of Merkel cell carcinoma: a case report and review of the literature. Int J Surg Case Rep. 2015;7C104-8. doi: 10.1016/j.ijscr.2014.11.027
  22. Bonvalot S, Ternes N, Fiore M, et al. Spontaneous regression of primary abdominal wall desmoid tumors: more common than previously thought. Ann Surg Oncol. 2013;20(13);4096-102. doi: 10.1245/s10434-013-3197-x
  23. Miller CV, Cook IS, Jayaramachandran R, Tyers AG. Spontaneous regression of a conjunctival malignant melanoma. Orbit. 2014;33(2);139-41. doi: 10. 3109/01676830.2013.851708.
  24. Diede SJ. Spontaneous regression of metastatic cancer: learning from neuroblastoma. Nat Rev Cancer. 2014;14(2):71-2 doi: 10.1038/nrc3656
  25. Buder T, Deutsch A, Klink B, Voss-Bohme A. Model-based evaluation of spontaneous tumor regression in pilocytic astrocytoma. PLoS Comput Biol. 2015;11(12):e1004662. doi: 10.1371/journal.pcbi.1004662
  26. Murphy KA, James BR, Guan Y, Torry DS, Wilber A, Griffith TS. Exploiting natural anti-tumor immunity for metastatic renal cell carcinoma. Hum Vaccin Immunother. 2015;11(7):1612–16.
  27. Kucerova P, Cervinkova M. Spontaneous regression of tumour and the role of microbial infection – possibilities for cancer treatment. Anticancer Drugs. 2016;27(4):269-277.
  28. Jhawar SR, Thandoni A, Bommareddy PK, et al. Oncolytic viruses-natural and genetically engineered cancer immunotherapies. Front Oncol. 2017;7:202. doi: 10.3389/fonc.2017.00202
  29. Corrigan PA, Beaulieu C, Patel RB, Lowe DK. Talimogene laherparepvec: an oncolytic virus therapy for melanoma. Ann Pharmacother. 2017:51(6):675-81. doi: 10.1177/1060028017702654
  30. Lee CH. Engineering bacteria toward tumor targeting for cancer treatment: current state and perspectives. Appl Microbiol Biotechnol. 2012;93(2):517-23. doi: 10. 1007/s00253-011-3695-3
  31. Howells A, Marelli G, Lemoine NR, Wang Y. Oncolytic viruses-interaction of virus and tumor cells in the battle to eliminate cancer. Front Oncol. 2017;7:195. doi: 10.3389/fonc.2017.00195
  32. Geng Q, Jiao P, Jin P, Su G, Dong J, Yan B. PD-1/PD-L1 inhibitors for immuno-oncology: from antibodies to small molecules. Curr Pharm Des. 2017 Oct 4. doi: 10.2174/1381612823666171004120152 [Epub ahead of print]
  33. Wilkins O, Keeler AM, Flotte TR. CAR T-cell therapy: progress and prospects. Hum Gene Ther Methods. 2017;28(2):61-6. doi: 10.1089/hgtb.2016.153
  34. Schreiber RD, Old LJ, Smyth MJ. Cancer Immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science. 2011;331(6024):1565-70. doi: 10.1126/science.1203486
  35. Cong Y, Shen G, Wu S, Hao R. Abscopal regression following SABR for non-small-cell-lung cancer: a case report. Cancer Biol Ther. 2017;18(1):1-3. doi: 10.1080/15384047.2016.1264541

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