ACR Institute’s Holistic Immunotherapy Protocol

The Holistic Immunotherapy (HIT) Protocol for Cancer Reversals and Longevity Optimization

« L’urgence en cancérologie, ce n’est pas d’opérer, mais c’est de traiter les micro métastases. » Prof. POUYARD Institut Curie (“The urgency in oncology is not to use surgery, but to address micro-metastases”)

Introduction

This Protocol is based on hundreds of empirically observed cancer reversals, decades of cancer and biogerontology research as well as on a pending CT (clinical trial). (1)

Cracking the Cancer’s Longevity Code

The ARC Institute’s HIT protocol’s rationale is to clear both cancer and senescent cells from human tissues as much as needed in order to restore the JDV (Joie de Vivre) Engin back to homeostasis. Once the immune system is holistically restored and epigenetically tweaked in a way that is consistent with biology, both cancer and aging (senescent) cells are better controled and reversed. And this happens without the damaging stresses of cytotoxic chemo, ionic burning radiation and to a lesser extent oncological surgery. The patient starts looking and feeling younger and stronger while achieving the NED status cancer-wise. (2) When this performance is achieved, cancer starts being more of a blessing in disguise.

Up to now, cancer cells are the only cells that have cracked the code of quasi endless longevity. As long as they have food and space, they will replicate without end. Far from being stupid, these cells have figured out how to trigger the off switch of the aging and apoptotic genes. (3) They are so good at this task that they will even delocate, squeeze, burst and repair their nuclei through all sorts of bodily obstacles in order to accomplish their metastatic mission. (4) (Exhibit A)  And the more they are attacked by conventional oncology’s weapons of mass cellular destruction, the stronger and more invasive  their cancer stem cells tend to get. (5)

How could they not, given the fact that mainstream oncology experts exert few if any safe and efficient interventions on the tumor’s milieu, the most important of which is the immune system. Indeed, we have known for many decades that N.K. and cytotoxic T cells are capable of removing cancer cells. (Exhibits B). Yet, until recently, (6) very little has been done in this realm. And when it has, via “check-point” inhibitors, inter alia, there are many expensive side effects, many of which costs hundreds of thousands of dollars per cancer patient. (7) Hence, the Institute’s preference for a more holistic and cost-friendly approach.

“Scientists have focused their attention on centenarians as optimal model to address the biological mechanisms of “successful and unsuccessful ageing”. They are equipped to reach the extreme limits of human life span and, most importantly, to show relatively good health, being able to perform their routine daily life and to escape fatal age-related diseases, such as cardiovascular diseases and cancer…”. Immun Ageing. 2012 Apr 23;9(1):8.
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Top: Cancer-free Longevity hotspots in the world: Over a dozen

The Institute’s General  Approach to Cancer Control and Reversal

Instead of conventional oncology’s necrosis-based mass killing strategy, the ACR Institute’s team prefers to use a gentle holistic approach that addresses advanced Longevity via the restoration of homeostasis, balance and resiliency within the body’s major bodily functions, including, but not limited to the immune system and cellular senescence. (See  Exhibit C). (8)

Once this objective is achieved, we focus on the 19 constituent step-by-step mini-protocols that are briefly summarized below. Depending on the person and the cancer, different combinations of the following mini-protocols will be recommended. Some cancer patient can benefit from just a few of these measures, while others need all of them.

Each “section” (mini-protocol) below targets a specific pathway or a series of pathways and signaling molecules that have been proven, beyond any reasonable doubt, to have important “anti-cancer” modulating effects in terms of cancer control and reversal, the most “holistic” impact of which is the activation of signaling pathways that can encourage cancer cells to redifferentiate back to the Community of healthy mortal cells, to revert back into normality. When this approach is not unattainable, the other general reversal strategies are based on cancer’s suicidal apoptosis mechanism, on tissue necrosis and lastly on getting holistically zapped by the T-cells’ endogenous cytotoxic chemicals (Cf Exhibit B), followed by phagocytosis. (9)

The ACR Institute’s 19 mini Protocols below are but general categories, each of which are made up of different techniques, each of which needs to be uniquely applied to each patient, and-or under the guidance of an experienced health professional when legally possible.

Preliminary Evaluation

Because Holistic Oncology is tailored to the patient’s genome, transcriptome, proteome and lifestyle, it is first necessary to evaluate the molecular biology of the tumor cell population and, in particular, its CTC and CSC spread (if any). We also need to review efficient and safe monitoring techniques to make sure the chosen options are consistent with evidenced-based progress in cancer control and reversal.

1. The Detoxification Protocol

Activating  detoxification pathways (metabolic and extrinsic). Three of the most important actors who are missing in the conventional oncology team is the toxicologist, the detoxification holistic practitioner and the microbiologist. The majority of cancers are triggered chemically, via pesticides, food additives, heavy metals, pollutants, viruses, bacteria  and the like. Yet, in the mainstream, very little is done to address these mutagenic agents. These carcinogenic compounds therefore need to be first identified by the toxicologist and microbiologist and secondly, the patient needs to remove, with the help of the holistic cancer experts, both these cancer-promoting microbes as well as heavy metals and toxic chemicals. (10) In this perspective, the Institute’s educates the patient-student in different detox modalities, from sauna therapy, to different forms of chelation and metabolic detoxification. Both optimal longevity and cancer control and reversal have been shown to prosper via different detoxification procedures

2. The Microbiota-Enhancing Hydration & Nutrition Protocol

Once the major emonctory and drainage organs have completed their detox task, the HIT protocol recommends one of three types of diets adapted to the patient’s genome, constitution, microbiota and health challenges, in this case, the type of cancer, its virulence, spread and nature. Although each of these anti-cancer diets work on common pathways, including, but not limited to the strengthening of the immune-surveillance system and the targeting of  glycolysis pathways, each of them has biochemical specificities, the targeting of which is bilaterally determined by both the patient and the nutritionist counselor. (11)

Clinical Nutrition, the microbiome and hydration are all inter-related. Different types of hydration approaches in conjunction with optimal nutrition and their superfoods nutrients can help to activate homeostasis and key longevity & anti-cancer genes and hormones while ensuring a better functioning of neuro-transmitters and brain chemistry.  Certain Longevity and superfoods or what has been called functional foods will be analyzed from goji and other berries and fruits, nuts to mushrooms, codyceps, plants, herbs (spices like turmeric, red peppers, garlic, ginger and many others) barks, cacao, roots, seaweeds, kimchi and other fermented and non fermented foods and beverages such as small amounts of “sulfite-free” red wine and polyphenol-rich teas. The importance of the microbiome and Vitamin B  12 and the relevance of the Mediterranean diet for a cancer-free longevity will be emphasized. (11 b)

3. Psycho-neuro-endocrinology anti-stress & Meditation Protocol

Once the body and its microbiota have been been cleansed, remineralized and correctly nourished, the third protocol focuses on stress management and brain-wave regulation. Nurturing emotional wellbeing and spiritual health is too often neglected in the mainstream, hence the poor results in conventional oncology. The evidence that confirms this claim is overwhelming. In this field, the Institute’s team teaches multiple psycho-neuro and neuro-science techniques, from different forms of meditation, to sophrology, visualization, breathing, acu-pressure and tapping, trauma therapy, musicotherapy and mindfulness, the effectiveness of which has been corroborated by many published studies.

In this perspective, the Institute’s Team is particularly fond of meditation medicine. The mind and emotions produce as many neuropeptides that modulate an abudance of signaling molecules as the body impacts the emotion and mind via the central nervous system’s feedback loop and the microbiota’s vegas nerve communication. One of meditation’s benefits is with regard to Telomere lengthening and telomerase activation. Since the 2009 Physiology Nobel winner Elizabeth’s Blackburn (et al) discovery of telomerase regulation, many telomerase promoting techniques have been identified and used with success, from TERT gene therapy, to meditation and other holistic techniques, all supported by published studies.

4. Caloric Restriction, Intermittent Fasting and the FMD

Caloric Restrictions , CR mimetics, time restrictive eating (Intermittent Fasting), therapeutic water fasts and the fasting mimicking diet can all favorably modulate cancer control and reversal.  But there are many different conditions that need to be met before this millenia medicine can be put in place. And any kind of dietary deprivation should be done under the care of a Fast expert. For over one hundred years, a large body of medical evidence shows that restricting calories at least 30-50% below average efficiently inhibits aging processes in all species tested. Different molecules like resveratrol and metformin can act as mimitics. Other techniques exist in holistic, integrative and functional medicine that need not deprive the body of nutritional contentment.

 5. The Anti-Inflammation Protocol

Turning off the fire of excessive free radicals, cytokines and other inflammatory processes are all permament fixtures of the HIT protocol. This general backdrop is important because one of the key drivers of both the aging process and the malignancy process is inflammation.

6.  Anti Growth Factors Protocol

Cancer’s goal being the total invasion of the host, the malignancy process activates and-or promotes many growth factors, from IGF-1 and mTOR, to VGF, EGFR, FVGT and many other growth pathways, all of which are inter-connected. Up to 2 millimeters, a tumor can not survive without the activation of angiogenesis, one of the key growth factors. It is therefore imperative to timely address this hallmark of the cancer process.  The Institute does this holistically.

7.  Anti Glycolithic Pathway Protocol

Cancer thrives on multiple mechanisms, including, but not limited to the glucose and glutamate pathways. Food and supplements can have an impact on this front. In this perspective, the Institute recommends  Holistic Techniques that target autophagy and, inter alia,  cellular respiration.

 8. Anti-coagulation Protocol

One of cancer’s characteristics is to thicken the blood so that its seeds (i.e., micro-metastasis) can better adhere and embed within distant tissues. To this end, the cancer process alters the coagulation cascade as well as the cell’s sodium-potassium pump and dispatches “adhesion” molecules to better colonize distant tissues. In addition to the promotion of metastasis, this process also produces clot formation, from which many cancer patient die. It is therefore necessary to correctly address this aspect of the disease.

Workshop on Hormonal and neurotransmitter boosting and balancing as tools to develop more "joie de vivre" (enjoyment of Life). Click picture for details.

Top: red hot peppers, a great way to boost endorphins, immune function and metabolic pathways. Image licensed under cc.

 9.  The Immuno-modulation Protocol

Immune-building, immune-modulation, re-activation of the innate immunity and the dendritic surveillance system are all “must do’s” if we are to significantly control and-or reverse the malignancy process. Moreover, by  restoring the immune surveillance system, the immune system will store the memory of the malignancy. This means that if a circulatory tumor and-or stem cell starts to colonize new tissues, the immune surveillance system will send an alert signal the the cyto-toxic T cells, which will move forward to remove cancer cells (See Exhibit B).

10. Genomic Stability Protocol

Cancer genes do exist of course and should be addressed. But not as a priority since the genetic process of cancer is downstream to more significant metabolic processes. In this perspective, the upregulating of anti-tumor genes like the P-53 and the downregulating (dormancy process) of tumor genes (oncogenes) like the RAS genes are as important as the targeting of repair and longevity genes insofar as cancer control and reversal are concerned.

In terms of  DNA repair,  thanks to innovative and holistic DNA repair activation and to DNA repair enzymes, the discovery of which was recognized by a 2015 Nobel Prize in Chemistry,  the body is able to repair defective DNA and altered signaling pathways. The rate of DNA repair is dependent on many factors, including the cell type, the age of the cell, and the extracellular environment. With time, a cell  accumulates a large amount of DNA damage, and can  no longer effectively repair damage incurred to its DNA. As a consequence, it can enter one of three possible states: (a)  an irreversible state of  inflammatory dormancy, known as senescence  (b) cell suicide, also known as apoptosis or programmed cell death (c) unregulated cell division, which can lead to the formation of a tumor that is cancerous. The DNA repair ability of a cell is vital to the integrity of its genome and thus to the normal functionality of that organism. In this mini protocol, we will examine key repair genes  (“Quantification of biological aging in young adults,” Daniel Belsky, Avshalom Caspi, et al. PNAS, July 7, 2015.) We will also examine innovative and holistic techniques that can enhance DNA repair mechanisms while reducing oxidative stress. With regard to certain cancers,  we will show how holistic savoir-faire can favorably impact over 500 cancer and cancer-suppressor genes.

11. The Transcriptome, Epigenesis, Peptides and Exosomes

The contributions of mRNA sequencnig and Epigenetic science have been eye-opening insofar as cancer and longevity are concerned. New discoveries with different peptides and exosomes have also contribued in the determination of a credible  cancer-free rejuvenation program. In this mini-protocol, we will examine what cancer and senescent clearing techniques can be activated from the confort of one’s home.

Stem cell driver

Top, the cancer stem cell driver, a too often forgotten “actor”  in the malignancy process

12. Cancer Stem Cells Protocol

Cancer stem cells have been shown to be the central engin of metastasis and the best prognosis tool we have. It is therefore imperative to both target and monitor the circulatory tumor and stem cells that are in the bloodstream. While there are presently RCT (clinical trials) on diffferent convventional drugs to obliterate these cancer stem cells, it will take many more years before they are brought to the market. Furthermore, they may be laden with serious side effects. However, holistic oncology already has non-drug tools to remove these circulatory cancer cells from the body.

On the other hand, non cancerous stem cells are quite beneficial for the entire body, including when systemic cancer strikes. At birth, we are endowed with around 20,000 stem cells. As age accumulates, the body tends to deplete these Master molecules, that which hinders tissue repair. From prolotherapy to tissue regeneration, stem cell differentiation and activation, innovative and holistic medicine in the realm of  stem cells have significantly impacted optimal longevity and cancer control-reversal.

13. Mitochondrial, hormonal and neurotransmitter biogenesis and restoration

New discoveries in cellular respiration, endocrinology, nutrition and neuro-science help us to understand not only how to prevent chronic diseases, but also how to successfully treat them, including, but not limited to Alzheimer’s Disease, Hashimoto, cancer and diabetes.  Concomitantly, emotional strain and chronic stress are also significant aging and carcinogenic factors that need to be addressed. In this mini protocol we will also show you how to monitor and rebalance one’s blood sugar levels and keep one’s insulin receptors as sharp as a merdeces’ spark plugs. Optimizing one’s mitochondria, lipid profile, thyroid function and revitalizing one’s sexual hormones and neurotransmitters are also important.

14. Micro-metastases Protocol

 This protocol looks into  anti-mitotic substances as well as  anti-cancer proliferation techniques, from electric regulation, electro-acupuncture, to oxygenation improvement, cellular homeostasis, atp normalization and selective malignant cyto-toxic natural substances that remove metastastic cells while inducing apoptosis among those cancer cells that have been resensitized to this mechanism.

15.  Physiotherapy, Heliotherapy and Electrotherapy Energy Enhancement Protocol

The evidence shows that those who exercise moderately fare better. To energy and immune boosting exercise, can be added massage, lymph activation, spinal adjustment, sacral cranium work, acupuncture, pmef, frequency modalities among other techniques. Brittle bones are often a consequence of both cancer treatment and the malignancy process. The patient needs therefore to strengthen the bones and all the more so that cancer in the bones is a painful process.

16. Oxidative Protocol

Oxygen is a key player in the recovery process. The HIT protocol investigates different modalities of oxygen intake, from the HBOT (hyperbaric oxygen chamber), to ozone therapy, Vitamin C IV therapy (in large dosages, vitamin C acts like a pro-oxidant), the floating chamber, the altitude chamber, to aromatherapy, the Bol de Jacquier technique, breathing exercises and more.

17. Supplementation Protocol

Depending on the cancer and the patient, different supplements, neutraceuticals, mushrooms and herbs can be indicated. In this protocol, we examine which are the most useful and which have the most scientific backing. Genomic individualized testing may also be needed in order to first know how the patient’s genes and proteins will react to a given supplement or molecule.

18  Cancer Pain, Cachexia and Tumor Lysis Management Protocol

Inflammation and lack of oxygen via tumor blockages create pain. It is therefore useful to know what integrative and holistic techniques exist to control and reverse pain without depressing the immune system or affecting nefariously other bodily functions. As for sarcopenia and cachexia (muscle-wasting), this is an end-stage cancer hallmark that can often be better controlled and even reversed. Tumor Lysis (also called cancer “die-off”) is important because if there are too much necrotic cancer tissues in the bloodstream, the kidneys can get overwhelmed.

19. Integrative Adjunctive Protocol

When  needed, the integrative or conventional techniques can be envisioned.  In this field,  low dose cytotoxic chemo and radiation (i.e., chemo-radiation) can be associated to hyperthermia, intermittent and-or prolonged fasting, antioxidants, autophagy modulators and, among other techniques, insulin potentiation therapy (IPT). Allopathic oncology’s cancer drugs can also be safer and more effective in combination, either with other drugs targeting complementary pathways or with neutraceuticals (supplements) and foods.  Low dose Naltrexone, Alpha Lipoic Acid, Vitamin C & K,  DCA, genestein, poly-mva, laetrile, cannabinoids, anti-fungals, and many other molecules like metformin can be envisioned in the integrative oncology perspective.  (12) Likewise with genetic and transcriptomic interventions (12 b)

telomeresPD
Top: chromosomes capped with protective telomeres. Image licensed under cc.

Conclusion

“In humans and other animals, cellular senescence has been observed to be connected to the shortening of telomeres with each cell cycle; when telomeres become too short, the cells die. The length of telomeres is therefore the “molecular clock”, Harvard Professor Hayflick.

Meta-analyses after meta-analyses have shown that for most of the  common solid cancers, mainstream cancer treatments based on cyto-toxic chemo-therapy bestow upon cancer patients less than a 3 percent “five years” survivability success rate. (13)

 “The overall contribution of curative and adjuvant cytotoxic chemotherapy to 5-year survival in adults was estimated to be 2.3% in Australia and 2.1% in the USA”. Cf. Morgan G1, Ward R, Barton, The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies. M.  Clin Oncol (R Coll Radiol). 2004 Dec;16(8):549-60.    (Source)

Not only can chemotherapy worsen the tumor’s micro-environment, it can also make the engins of metastases, the cancer circulating stem cells, mutate and spread even more.  Radiation has a similar effects. (Source)  Likewise with many biopsies and surgeries, they too can significantly contribute to the spreading of  the malignancy, via the cellular adhesion, immune suppression, surgical stress and inflammatory pathways. And to make matters worse, many conventional diagnoses and prognoses have built-in and often  fatal flaws. 

While there have been some progress with Conventional Oncology Research, the Allopathic Model still appears to be flawed. If only because none of the conventional anti-cancer approaches take in consideration the patient’s “placebo-based” abilities. On the other hand, Holistic Oncology never neglects the power of hope and placebo. One of the fundamental principles of holistic medicine is to bring back the “joie de vivre” (i.e. enjoyment of life) element in medicine. We maintain that this “placebo” element is often more therapeutic than many invasive conventional anti-cancer therapeutics that use necro-interventions and nocebo-policies without fully respecting Dr Hippocrates’s “primum non nocere” rule (i.e., “first do no harm”).

For now, holistic immunotherapy approaches have been decreed by those who have taken over the American Government to be illegal to practice. However, the First Amendment guarantees its free expression. Thus, we can teach it, in particular its constituent elements (ie, the 19 mini protocols outlined above). (14) Thereafter, it will be up to the patient to choose the best course of action, including self-medication, (15) according to his or her understanding and in light of his or her doctors’ recommendations. (16)

Once the student patient personally witnesses the Institute’s Holistic immunotherapy Protocol’s favorable impact on cancer markers, he or she will also witness that many other markers including longevity markers are also improving. (17) At this point, the cancer diagnosis will become less a  fear-based curse than a wake-up call and an opportunity to live holistically, with “extra” life extension, with meaning and with robust consciousness.

Even if cancer were to be eradicated, given the other chronic diseases and the modern culture of accelerated aging, we would only gain around 2.5 extra years before succombing to another  age-related chronic disease that would also accelerate cellular senescence, debilitation and the coming of death. This is another reason why the ACR Institute prefers to focus on Holistic immunotherapy and Optimal Longevity rather then just another “alternative” cancer protocol.

Pr. Joubert (ACR Institute Director)

Exhibit A

Comment on Cancer Cells Video

As we see in the Top Video, cancer cells are extremely “determined” and robust in expressing their genetic mission of conquering the cellular matrix, whatever the difficulty. They will even bleed their nucleus in order to get through the trenches. And when their nuclei explodes and then leaks, they will repair illico presto the damage and continue their imperial tasks

Exhibit B

Comment on the Killer T Cell Video

As we see in this second Top Video, Evolution or Nature has created a formidable foe to face cancer cells. This foe is a special agent of our immune system, called the cytotoxic or killer T cells, whose genetic mission is to  seek out and destroys foreign or detrimental cells—including cancer cells, deleterious viruses and bacteria—that might be lurking in the body for no good reason, a process that takes about 10 minutes from cancer cell detection to explosive apoptotic death.

One of the Central Mechanisms of Cancer Cell Death

These T cells enduce cancer and damaged cells to commit suicide via “fireworks” apoptosis, as seen in this video.  T cells do not need to be engineered to do this, they’ve been designed for this task for millions of years.  Thanks to powerful electron microscopes, inter alia,  we can see how these cytotoxic T cell chase, envelop and induce cancer cells to commit suicide, via an explosive apoptosis “finish”.

This cell testimony is compelling proof that one of the keys to reversing the cancer epidemic has been neglected for too long. True, one of cancer’s hallmarks is to secrete enzymes to trick the immune system to not attack cancer cells. True, many cells including fibroblasts and microbiota critters allow themselves to be recruited on behalf of Cancer’s mission. But the immune system and everything else can be holistically tweaked for cancer cells to be cleared. No need to spend billions of dollars to engineer the immune system to recognize and attack cancer cells. And all the more so that this procedure can produce dangerous auto-immune diseases where the T cells will go after healthy tissues, like the thyroid, pancreas or even the brain.

At ACRI, we prioritize the study of any and all credible immune-therapy option that addresses safely and efficiently the body’s innate and adaptive immune system. Once the immune system is restored holistically, it is not only possible to durably prevent most cancers, but it is also possible to clear both cancer and sensecent cells and all the more so that the human innate immune system can store the memory of all antigens, including cancer cell antigens, thereby ensuring sustainable protection and extra longevity thanks to the immune system’s concomitant removal of senescent cells. If anything accounts for healthy supercentenarian longevity, it is a robust immune system.

Cancer microenvironment

Cancer microenvironment

Exhibit C

Senescent Cells are inseparable from cancer cells and one of the key pathways to accelerated Aging and premature death. Therefore, by holistically addressing senescent cells, (and vice versa), we will be necessarily promoting the clearing of both these inflammatory, damaging and misguided cells, thanks to which it will be much easier to significantly extend Life to a healthy post centenarian lifespan, in conformity with our evolutionary design and the Bible’s revelation (Genesis 6:3 speaks about 120 years).

Top video: In the Institute’s Optimal Longevity Coaching sessions, we share the cutting edge up-to-date information and published studies that show how we can clear a good amount of these senescent cells. The techniques we propose are both holistic in nature and scientific in structure. They are therefore safe, efficient, reliable and cost-friendly. By addressing this aging pathway, called “cellular senescence”, the cancer patient will be thus in a better position to significantly turn down the inflammatory cancer-fueling wild fire that burns down his or her vital bodily functions. And as a bonus, the patient will  receive meaningful longevity benefits, most of which will help to ward off the other diseases of aging.

To learn about Coaching & Training Sessions, click here.

To view the Institute’s Private coaching Secrets on Cancer cells’ Biological Strengths and Weaknesses

 Click Here (Password protected)

Students  will be able to access many key  videos that will teach them key biological processes and newly discovered pathways that spur cancer cells to be who they are and how we can out-wit, with holistic savoir-faire, their formidable conquest strategies.  As a result, coached patients will be more motivated to go  holistic in the direction of great cancer control and malignancy reversal.

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Text Still under Construction

References

(1). The Institute is organizing its first fundraiser via FB. Part of the collected funds will go into organizing the Holistic Immunology Trial (HIT). Thereafter, we will organize a fundraiser to complete the Institute’s Clinical Trial. The general purpose of this human clinical trial is to show that Holistic Immunology can both resolve most cancers while optimizing human longevity to a supercentenarian status.
(2). NED = no evidence of disease. However, the Institute does not use the same diagnostic markers as conventional oncology. Just because medical imagery and biomarkers dont show traces of cancer cells does not mean there are no cancer cells in the body, including cancer stem cells that can form new tumors within a few months to a few years after the NED diagnosis. Only recently have we uncovered similar biochemical pathways that both aging and cancer share. One of those pathways is connected to senescent cells. These non mitotic cells tend to clogg up and destroy surrounding tissues. They have been identified as a key player in elderly inflammation, cancer and accelerated aging. Normally it is the immune system that clears them. When a patient’s immune system weakens, that person becomes vulnerable to both cancer and accelerated aging. However, it is quite doable to holistically boost the cancer patient’s immunity so that their dendritic cells will recognize both senescent and cancer cells, thanks to which signaling molecules get dispatched to inform the  lymphocyte T Killer cells so seek and destroy cancer and senescent cells, thanks to the selective chemo they have in their back-pack, a chemo that is specific to the cancer and senescent cells and that does not harm the rest of the healthy tissues.
(3). The longest cancer cell alive today is from the 1950s, known as the Hyla cancer cell. Experts call this cancer cell line “immortal”.
(4). Chemoresistance is the name cancer experts give to cancer cells who have adapted to cyto-toxic chemo. Cancer stem cells are known to become more aggressive and invasive when they get blasted with chemo. They will just express new genes which will make stronger proteins that will accomplish it’s mission of invading all tissues. Likewise with radiation. (Source)
(5). As Exhibit A shows, cancer cells are quite robust, to get to their objective, they will even burst their nuclei open and immediatly after, activate their repair mechanisms in order to put everything back in place for the continued charge against the host.
(6).  This year’s (2018) Nobel in Medicine has gone to cancer immunotherapy.
(7). There are still many defects and toxic effects with conventional immunotherapy. See Blog.
(8). This “restore all imbalances” strategy was first codified in Chinese medicine thousands of years ago. The “kill and suppress the diease’s symptoms” model is typically the Western conventional way of thinking and practicing medicine.
(9).  Although To date the exact molecular mechanism by which macrophages recognize and phagocytose tumor cells remains unclear, we nonetheless know that these macrophages do ingest tumor cells. One of the mechanisms by which this process has been partially elucidated is via the  activation of Toll-like receptor (TLR) pathways, thanks to which  macrophages can induce the phosphorylation of Bruton’s tyrosine kinase (Btk), which then catalyzes cell-surface exposure of calreticulin. Calreticulin  secreted by macrophages plays a critical role in mediating adjacent tumor cell recognition and phagocytosis. Mingye Feng et al, Macrophages eat cancer cells using their own calreticulin as a guide: Roles of TLR and Btk, Proceedings of the National Academy of Sciences of the United States, (2014) Source
(10). Conventional doctors are not trained in targeting metabolic and extrinsic detoxification pathways, from the liver’s gluthione-assisted metabolic detox, to kidney, colon, blood, lung and the skin drainage systems. In this realm, the HIT protocols involves multiple holistic techniques that help to remove toxicants as well as deleterious bacteria, molds and viruses.  Some oncologists like Dr Simoncini (who the Institute has interviewed, link) claim that cancer cells are fungi. While they may adopt some fungi behavior and even contribute to the carcinogenesis process, the Institute has determined that they are not fungi. See link.
(11). Food-medecine is usually not enough to completely reverse cancer, but it’s an important part of the ACR Institute’s cancer control and reversal strategy. The Institute scientists have determined multiple diet varieties within three general diet categories: raw plant-based, vegan ketogenic and the Mediterranean regime. Homeopathic and-or moderate dosage of organic wine with meals is also considered part of the HIT’s clinical nutrition protocol as is vibrant spring alkalinic and structured water. All three of these diets are “paleo” in that they are based on ancestral and evolutionary biology. But meat of any sorts (save wild fish) is not recommended. For those who can afford this test, the preliminary Microbiome  Viome Test will indicate what foods will best feed the microbiota,  which is one of the key players in both cancer reversals and longevity optimization. If the  patient can not afford this test, we sill use either a simple stool test or clinical observation
(11 b).  There are different variants of the Mediterranean lifestyle reputed to enhance chronic-diseased free longevity, from France, Spain, Italy, Greece, Maghreb, (North Africa) Machrek (in particular Lebanon and Syria), Israel and Turkey. The Institute’s team has taken the best nutritional techniques from these culture and fine-tuned the Med Diet to an improved version that promote cancer-free longevity.
(12). The science that comes out of Academia, Bio-tech companies’ R & D, the government’s cancer research centers are often relevant in terms of better understanding cancer’s diagnoses, its mechanisms of action and even regarding cancer control interventions.  But what the Industry chooses to invest in is necessarily selected, first and foremost in terms of profitability. Thus, the proposed double-blind based “standards” almost always extend time without fully reversing the malignancy.  As a consequence, it is reasonable to use the best of the two worlds. Conventional science to better understand cancer’s behavior and to control cancer growth in conjunction with holistic tradition and wisdom in order to know what intervention can be the best standard of care for the patient and the reversal of the malignancy. As for the more conventional and somewhat invasive targeted therapies, in exceptional circumstances, these techniques can also be envisaged. Anti-angiogenesis targeted drugs like avastin, or growth factor inhibitors like Herceptin (e.g. HER2 + for breast cancer) or EGFT blockers, check-point inhibitors and CAR therapy, among others techniques that can as a last resort and-or as adjunctive care be considered when the more holistic and less invasive primary treatments fail.
(12 b). Browner, WS; Kahn, AJ; Ziv, E; Reiner, AP; Oshima, J; Cawthon, RM; Hsueh, WC; Cummings, SR. (2004). “The genetics of human longevity”. Am J Med 117 (11): 851–60
(13). While conventional oncology has been more successful with the “liquid” cancers (e.g. lymphomas and leukemia), it has over-all failed with the safe and efficient control and reversal of the “solid” cancers, which constitute the vast majority of malignancies that affect humans. Resistance to chemotherapy and molecularly targeted therapies have been major problems facing cancer research and praxis decades. The mechanisms of resistance to  conventional cytotoxic chemotherapeutics and to therapies that are designed to be selective for specific molecular targets share many features, such as alterations in the drug target, activation of prosurvival pathways and ineffective induction of cell death. (Source). But in the end, most advanced cancer patients tend not to survive relapse. For the last couple of years, there has been another form of cancer therapy that has been brought to the marker. These are called immunotherapeutics. These immune-based treatment drugs are known as checkpoint inhibitors. It’s been shown that they  can sometimes restore T cells’ ability to recognize and destroy cancer cells. The risk with this type of treatment however is that it can trigger excessive immune responses against healthy tissue. Furthermore,  current immunotherapy drugs work for only a small subset of patients like melanoma patients. The newest type of treatment, chimeric antigen receptor T cell therapy, involves removing a sample of T cells, genetically reprogramming them in the laboratory to attack cancer cells and putting them back into the body. So far, CAR-T has been most successfully used to treat blood cancers such as leukemia and lymphoma. Here, too, there is a risk of overstimulating the immune system and causing inflammation of healthy tissue.
(14). There are many other aspects to cancer control and reversal that can need prompt attention, one of which is the repairing and-or correcting of allopathic oncology’s damages, when possible, from cancer wounds that don’t heal well, to traumatizing surgeries, to radiation fibrosis, to chemo brain fog, to immune and gut destruction and cancer stem cell spread etc. Depending on the drug used, ROS (ie, reactive oxygen species)  or autophagy can favor or inhibit the applied treatment. Therefore a potential new way of cancer treatment might be to include antioxidants or autophagy inhibitors to inhibit cytoprotective ROS-induced autophagy during the course of treatment. Cf. Poillet-Perez L1, Despouy G1, Delage-Mourroux R1, Boyer-Guittaut M2. Redox Biol. 2015;4:184-92. Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy. Redox Biol. 2015;4:184-92.
(15). With the patient’s pro-active upbeat attitude, he or she may be able to control and reverse the malignacy, even advanced cancers, with less invasive and more holistic, safe, efficient and cost-friendly techniques, the monitoring of which is crucial. (See ACR Institute diagnosis and monitoring tests for different tests). Given cancer’s exponential growth, time is of essence, therefore, regular monitoring is important, including, but not limited to the monitoring of circulatory cancer stem cells, as they are responsible for micro-metastases. This way, when we see good lab results, we can feel confident that the chosen protocols are working. Everyone one is different, therefore an individualized approach is important.
(16). With well-designed  holistic and metabolic cancer protocols, cancer patients can expect a  50 to 100 percent survivability success rate, defined as at least five years of remission, with few if any deleterious and toxic effects. See Blog.
(17). In this perspective, what is. striking with supercentenarians (above 110 years) like Jeanne Calment and hundreds of others is that they all nurture a rich-community like village entourage where stressors are very low. Having escaped acquiring Society’s common chronic diseases that un-necessarily kill millions of Americans each year, such as heart disease, cancer, stroke and diabetes, these centenarians and supercentenarians eventually do succumb, but not to cancer. These supercentenarian usually die from Senile Systemic Amyloidosis or a related amyloidosis that alters proteins,  which start to stick to the inside of blood vessels thereby restricting blood flow and creating inner havoc. (Source)   The mechanism by which amyloidosis progresses involves a slow process in which a native protein called Transthyretin, which transports thyroid hormones to the body, becomes increasingly unstable. As humans age and-or cease to maintain themselves holistically, the carrier protein begins to unravel and misfold, sticking to the inside of blood vessels and restricting blood flow in different organs. (L. Stephen Coles, Robert D. Young, Supercentenarians and transthyretin amyloidosis: The next frontier of human life extension, Preventive Medicine, 2012). This degenerative process can be compared to the metastatic malignancy process. Conventional medicine has been unable to reverse any form of amyloidosis. On the other hand, the ACR  Institute’s expertise team has accumulated compelling evidence that shows that this disease can also be better controlled if not reversed with innovative science and advanced holistic medicine.

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