List of hormonal cytostatic antineoplastic agents

Estramustine phosphate, the only dual hormonal and cytostatic antineoplastic agent to have been marketed. A normustine and phosphateester of estradiol. Used in the treatment of prostate cancer.

This is a list of dual hormonal and cytostatic antineoplastic agents.

  • Estramustine phosphate (Emcyt, Estracyt; Leo 299, NSC-89199, Ro 21-8837/001; estradiol 3-[bis(2-chloroethyl)carbamate] dihydrogen phosphate)

  • Prednimustine (Mostarina, Sterecyst; chlorambucil prednisolone ester; prednisolone 21-(4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate))

  • Alestramustine (estradiol 3-(bis(2-chloroethyl)carbamate) 17β-(L-alaninate))
  • Atrimustine (bestrabucil, busramustine; KM-2210; estradiol 3-benzoate 17β-((4-(4-(bis(2-chloroethyl)amino)phenyl)-1-oxobutoxy)acetate)
  • Cytestrol acetate (1α-hydroxyethinylestradiol 3-(bis(2-chloroethyl)carbamate) 11α,17β-diacetate)
  • Estradiol mustard (NSC-112259; chlorphenacyl estradiol diester; estradiol 3,17β-bis(4-(bis(2-chloroethyl)amino)phenyl)acetate)
  • Estramustine (Leo 275, Ro 21-8837; estradiol 3-(bis(2-chloroethyl)carbamate) ester)
  • Estromustine (Leo 271 f; estrone-cytostatic complex; estrone 17β-3-N-bis(2-chloroethyl)carbamate)
  • ICI-85966 (Stilbostat; diethylstilbestrol bis(di(2-chloroethyl)carbamate)
  • Phenestrol (fenestrol; NSC-183736; hexestrol bis[4-[bis(2-chloroethyl)amino]phenylacetate)

  • LS-1727 (nandrolone 17β-N-(2-chloroethyl)-N-nitrosocarbamate)
  • Sturamustine (dehydroepiandrosterone 17β-N-(2-chloroethyl)-N-nitrosourea)
  • Testifenon (testiphenon, testiphenone; chlorphenacyl dihydrotestosterone ester; dihydrotestosterone 17β-(4-(bis(2-chloroethyl)amino)phenyl)acetate)

  • Cortifen (cortiphen, kortifen, fencoron; chlorphenacyl 11-deoxycortisol ester; 11-deoxycortisol 21-(4-(bis(2-chloroethyl)amino)phenyl)acetate)


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