A paradigm shift in cancer theory and treatment has already taken roots. But the legal standard of care is still the same it has been for over 60 years, based on the postulate or dogma that cancer is solely a genetic disease thanks to which the tumor must be destroyed aggressively by chemo-poison, radiation and surgery.
The Institute’s Scientific Team believes this approach is misguided and that a more holistic paradigm is needed if we are to control and reduce the epidemic of cancer.
Among other complementary approaches, we need approaches that can activate metabolic and mitochondrial pathways that impact the cancer cell’s micro-environment and energy production system (1) in conjunction with metabolic and extrinsic detoxification protocols.
This is exactly what the ACR Institute’s scientific team has been involved with.
ACR Institute’s metabolic approach to cancer is based on individualized nutrient-dense Ketogenic (fat-based) (2), Plant-based and Mediterranean diets (3), including, but not limited to alkalinic structured Spring water and small quantities of quality organic wine, (4) in combination with a specific type of caloric restriction in synergistic association with herbal-based hyperthermia (heat), energy medicine (including acupuncture) supplementation, metabolic detoxification and, among other constituent elements, growth receptors inhibitor and metabolic blockers that beneficially affect cancer cell metabolism and ATP energy production, to the point of significantly controlling cancer growth.
MECHANISMS OF ACTION
Thanks to the deprivation of key molecules malignancy thrives on and because of the promotion of other no less key micro phytonutrients the ACR Institute recoomends, wellbeing genes get switched on, meaning that tumor suppressor and longevity genes will be holistically expressed while oncogenes will get downregulated to the level of promoting pro-apoptotic pathways that lead to the suicidal disappearance of cancer cells.
As Professor Otto Warburg showed over 90 years ago in 1923, (5) this epi-genomic wellbeing restoration occurs primarily because cancer cells use predominately glycolysis (fermentation) energy, given the fact that they have a defective production of energy mitochondrial system that is incapable of using oxidative phosphorylation (Krebs Cycle) efficiently. (6)
THE PREPONDERANCE OF THE EVIDENCE
For neuroblastoma malignancy, the current standard of care includes maximal surgical resection, radiation therapy and chemotherapy and temozolomide (TMZ), including the selective use of glucocorticoids for symptom control and complementary drugs for pain management. Yet, while treatments do shrink much of the tumor, the damaged micro-environmentt created from the use of these conventional weapons will actually promote cancer stem cell mutation-activation, the result of which is metastasis, recurrence and death. (7)
There is therefore a need to find another approach.
In the case below, we show strong evidence that our mammalian cousin, the naked mice, who shares almost the same genome as us (26,000 genes for humans and 16 to 23,000 genes for our rodents brothers) will respond beneficially to the cancer challenge if a more holistic gentle approach is engaged.
To this end, the following is what was done to them by the lab technicians: Xenografts were established in CD-1 nude mice (8) by subcutaneous injection of two neuroblastoma cell lines having distinct genetic characteristics and therapeutic sensitivity: SH-SY5Y and SK-N-BE(2). (9) The nude mice thereafter were randomized to four treatment groups receiving standard diet, calorie-restricted standard diet, long chain fatty acid based ketogenic diet or calorie-restricted ketogenic diet. Tumor growth, survival, metabolic parameters and weight of the mice HI monitored. Cancer tissue was evaluated for diet-induced changes of proliferation indices and multiple oxidative phosphorylation system parameters (respiratory chain enzyme activities, western blot analysis, immunohistochemistry and mitochondrial DNA content). The inescapable results:
“Ketogenic diet and/or calorie restriction significantly reduced tumor growth and prolonged survival in the xenograft model. Neuroblastoma growth reduction correlated with decreased blood glucose concentrations and was characterized by a significant decrease in Ki-67 and phospho-histone H3 levels in the diet groups with low tumor growth. As in human tumor tissue, neuroblastoma xenografts showed distinctly low mitochondrial complex II activity in combination with a generalized low level of mitochondrial oxidative phosphorylation, validating the tumor model. Neuroblastoma showed no ability to adapt its mitochondrial oxidative phosphorylation activity to the change in nutrient supply induced by dietary intervention.” (10)
OBSERVATIONS INFERRED FROM THE DATA
By targeting the metabolic characteristics of neuroblastoma with a precise caloric-restricted based ketogenic diet, most of the rodents were gently guided toward cellular stabilization.
In addition to in vitro and in vivo evidence that this protocol helps to control cancer growth, we have human anecdotal evidence from several ketogenic cancer survivors that show that humans behave like the mice mentioned above. When gently treated with a more holistic approach, they too had their cancerous cells stabilized. (Cf the Institute’s cancer testimonial register). (11)
CRITICAL APPRAISAL: HOWEVER, KETOGENIC DIETS ARE USUALLY NOT LONG-LASTING IN THEIR ANTI-CANCER BENEFIT
The ketogenic diet in itself is not the “magic bullet” or the decisive solution to the cancer challenge. Dr Atkins and other physicians have confirmed that cancer can outsmart this glucose fuel deprivation ketogenic approach by switching genes that activate other pathways, (12) including but not limited to the glutamine pathway. In this way, cancer cells use other fuels than glucose to overwhelm the host.
But cancer cells are still weakened when the cancer survivor decides to produce lots of ketones for the body’s energy supply. Because this fuel is well tolerate by healthy human cells but can’t be efficiently used by cancer cells, cancer gets weakens and stabilization tends to set in.
The ketognic-based diet, just like the Mediterranean and Plant-based diets, can therefore help to temporarily stabilize and weaken the cancer process .
But for more durable remissions and permanent reversals, other holistic modalities the ACR Institute’s Research Team has identified and partially published in its Protocol section need to be combined to the ketonic-caloric restriction protocol.
This is the fundamental objective of the ACR Institute’s clinical trial: to test over time metabolically-based energy-enhanced holistic approaches to both advanced malignancies and early-detected ones.
Emerging and compelling scientific evidence, a tiny amount of which we produced in this article, corroborates beyond any reasonable doubt that impaired cellular energy metabolism is the central defining characteristic of nearly all cancers regardless of cellular or tissue origin.
In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, most cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. We have seen that the fermentation cancer energy system that allows the cancer cell to proper is a nefarious growth that occurs at the expense of the host’s integrity.
Contrarily to the mainstream cancer bio-tech Industry’s belief system, genomic instability and essentially all of the other hallmarks of cancer, including aerobic glycolysis (Warburg effect), can be traced to this mitochondrial impairment.
Although the biotech Industry’s cytotoxic chemotherapeutic agents, allopathic drugs and radiotherapy can be useful when properly applied as adjunctives and in extreme cases as needed, (8) too often chemo and radiotherapy techniques destroy the host’s immune system and other important tissues while making cancer stem cells mutate and get stronger.
As a proximate result, these cancer stem cells become more resistant to conventional target therapy, they become more aggressive and are spurred to metastasize as circulatory tumor cells, thereby leading to distant colonization, that which precipitates higher recurrence rates, more suffering and premature deaths.
NEED FOR MORE CLINICAL TRIALS THAT CAN VALIDATE HOLISTIC ONCOLOGY TO BE THE NEXT NEW STANDARD OF CARE FOR CANCER PATIENTS
While Research and clinical practice have shown both safety and efficiency in the nutritional aspect of the metabolic approach, there is still room for improvement, including, but not limited to combination therapies, therapeutic dosage, epigenetic and neuro-pscho-immunological restoration.
The ACR Institute, for its part, is doing what it can with its blog production and its organization of two pending clinical trials to show that holistic techniques have a propensity to be both pre-clinIcally and clinically superior to conventional oncology.
Furthermore, in cooperation with holistic and advanced cancer research Institutes like ACR Institute which examine all credible data and not just tumor-shrinking drugs, responsible pharmaceutical companies should contribute in the paradigm-shift by investing more in neutraceuticals, combination therapies (and molecules), immunotherapeutic agents, circulating stem cell targeting, metabolic and glycolysis inhibitors and clinical nutrition instead of systemic cytotoxic chemo-radiation, which can be kept for only extreme rare cases.
PRECISION AND REFERENCE NOTES
(1). One of the key proponents of the metabolic approach to cancer is Professor Seigfriend. He has shown that the emerging evidence indicates that cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation. Dr Gonzalez used another variant of the metabolic approach (See Video section).
(2). The goal of metabolic ketogenic-based cancer therapy is to restrict cancer cells of glucose, their main energy substrate. The ketogenic diet targets tumor energy metabolism by lowering blood glucose and elevating blood ketones (β-hydroxybutyrate) via a fatty diet.
(3). That which usually includes red wine, in moderation or homeopathically, that which also benefits overall health. Cf. Pérez-Guisado J, Muñoz-Serrano A, Alonso-Moraga A. Spanish Ketogenic Mediterranean Diet: a healthy cardiovascular diet for weight loss. Nutr J. 2008;7(1):30. doi:10.1186/1475-2891-7-30.
(4). Because wine in moderation can help to increase the good cholesterol, help with vascular health and lipid digestion, be an aromatase inhibitor and activate key pathways, we include red organic wine either in moderation and-or homeopathically within the ACR Institute’s clinical trial protocol. Cf. Corder R, Mullen W, Khan NQ, et al. Oenology: red wine procyanidins and vascular health. Nature. 2006;444(7119):566.
(5). Otto Warburg got two Nobel prizes for his cancer discovery.
(6). In 2010 researchers from the NCI showed that metformin, the diabetes drug which reduces blood sugar levels, was linked to lowered levels of lung cancer. Other synthetic drugs have been used with success, including synthetic vitamin C in IV infusion . Plant-derived chemo agents have also worked, but in combination with different integrative and holistic oncology techniques for optimal results and in order to minimize the toxic side effects. These chemo agents have been more successful with the liquid cancers since these cancers usually have fewer genetic mutations than the solid malignancies. Likewise with radiotherapy, provided hyperthermia and other techniques are also used.
( 7). Neuroblastoma is a malignant pediatric cancer derived from neural crest cells. It is characterized by a generalized reduction of mitochondrial oxidative phosphorylation. It is an aggressive and often fatal malignancy of the central nervous system. Despite extensive research and clinical trials over the past 50 years, very little progress has been made to significantly alter its lethal prognosis. See the ACR Institute’s cancer stem cells research findings.
(8). Nude mice is the official name.
(9) Morscher RJ1, Aminzadeh-Gohari S2, Feichtinger RG2, Mayr JA3, Lang R4, Neureiter D5, Sperl W3, Kofler B2.Inhibition of Neuroblastoma Tumor Growth by Ketogenic Diet and/or Calorie Restriction in a CD1-Nu Mouse Model. PLoS One. 2015 Jun 8;10(6).
(11). One piece of emerging evidence that shows that cancer is not a genetic disease comes from the experimentation with the transfer of the tumor cell’s nucleus to the cytoplasm of normal cells containing normal mitochondria. That nucleus-changed cell did not become cancerous. If cancer were a genetic caused disease, the normal cell would have become cancerous. The genomic instability observed in tumor cells and all other recognized hallmarks of cancer highlighted by Professor Weinberg have been considered downstream epiphenomena of the initial disturbance of cellular energy metabolism, including the inflammatory process, as had noted Professor Otto Warburg decades ago. We therefore need to replace fermentable metabolites like glucose with respiratory metabolites, primarily ketone bodies. This metabolic dietary intervention will in most cases be anti-angiogenic (ie reduction of tumor vascularity) and even anti-inflammatory, while enhancing apoptosis, or tumor cell death and the immune system. Especially when caloric restriction is combined. Cf. Cao, S. X. Dhahbi, J.M., Mote, P.L. & Spindler, S. R. Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 10630-10635.
(12). For a more complete discussion on the long term failure of Dr Atkin’s case studies regarding the ketogenic diet and the absence of hard proof that the classical ketogenic diet works long term, please see the Institute’s publications and workshops.
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