GcMAF & Cancer Immunity

GcMAF (or Gc protein-derived macrophage activating factor) is a protein produced by modification of vitamin D-binding protein.[1]

 

GcMAF has not been properly studied in clinical trials and its laboratory results still need to be confirmed independently. So far, all claims on the efficacy of this product have no solid scientific basis. Its marketing is illegal; therefore there is no controlled guarantee on the quality of the product for human consumption sold over the internet.

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Anticancer Res. 2013 Jul;33(7):2917-9.

Clinical experience of integrative cancer immunotherapy with GcMAF.

Inui T1, Kuchiike D, Kubo K, Mette M, Uto Y, Hori H, Sakamoto N.

Author information

Abstract

BACKGROUND:

Immunotherapy has become an attractive new strategy in the treatment of cancer. The laboratory and clinical study of cancer immunotherapy is rapidly advancing. However, in the clinical setting, the results of cancer immunotherapy are mixed. We therefore contend that cancer immunotherapy should be customized to each patient individually based on their immune status and propose an integrative immunotherapy approach with second-generation group-specific component macrophage activating factor (GcMAF)-containing human serum.

PATIENTS AND METHODS:

The standard protocol of our integrative cancer immunotherapy is as follows: i) 0.5 ml GcMAF-containing human serum is administered intramuscularly or subcutaneously once or twice per week for the duration of cancer therapy until all cancer cells are eradicated; ii) hyper T/natural killer (NK) cell therapy is given once per week for six weeks; iii) high-dose vitamin C is administered intravenously twice per week; iv) alpha lipoic acid (600 mg) is administered orally daily; v) vitamin D3 (5,000-10,000 IU) is administered orally daily.

RESULTS:

By March 2013, Saisei Mirai have treated over 345 patients with GcMAF. Among them we here present the cases of three patients for whom our integrative immunotherapy was remar

https://www.ncbi.nlm.nih.gov/pubmed/23780980

 

 

Public warning issued by the Anticancer Fund[2]

Biochemically, GcMAF results from sequential deglycosylation of the vitamin D-binding protein (the Gc protein), which is naturally promoted by lymphocytes (B and T cells).[3] The resulting protein may be a macrophage activating factor (MAF).[3] MAFs are lymphokines that control the expression of antigens on the surface of macrophages, and one of their functions is to make macrophages become cytotoxic to tumors.[4]

December 2017 Efranet had obtained an orphan designation from the FDA for use of GcMAF in recurrent respiratory papillomatosis[16] and said that it was conducting a Phase I trial in Israel.[17]

“Vitamin D binding protein macrophage-activating factor”. AdisInsight. Retrieved 7 September 2017.

Bournemouth Echo saying there are over 300 scientific research papers, peer reviewed and published in major scientific journals, 11 of them with her name on them. In fact, GcMAF has 20 beneficial effects in the body.  GcMAF is naturally made in the body by removal of two sugars from Gc-Protein in blood.  This process can be replicated in the laboratory to produce billionths of a gram of GcMAF, which is all you need.

Furthermore, the U.S. Department of Defense actually funded a study of GcMAF, which “shows strong inhibitory activity of GcMAF on prostate tumor cells independent of its macrophage activation.”6 Cancer Research UK is not oblivious to this published science, because for years they’ve had a webpage denigrating GcMAF.

The GcMAF Genie Has Escaped From the Bottle

Despite efforts to quell efforts to commercialize GcMAF as a therapeutic agent for cancer, it has escaped from an attempted stranglehold by health authorities.

A developmental drug company in Israel is proceeding ahead with preliminary human safety studies using GcMAF. The company, EFRANAT, provides a convincing visual picture of the promise posed by GcMAF in photographs of a dog that experienced complete disease-free recovery from T-cell cutaneous lymphoma with GcMAF therapy.  The dog experienced a complete curative effect after only three injectable doses of GcMAF (see below).7

 

Summary of results:  2 of 14 dogs experienced complete recovery; 7 of 14 dogs experienced shrinkage of their tumors and their cancer stabilized and did not spread; 5 of 14 dogs did not respond to treatment.

Moreover, some of these doctors accomplish full recovery of 60% of non-verbal autistic children and were said in news reports to have discovered that vaccines are laced with an enzyme, nagalase (N-acetyl-galactosaminidase) that facilitates the spread of cancer. GcMAF drastically reduces nagalase levels, and treats many vaccine-induced diseases.22

Of considerable interest is the known fact that naked (hairless) mole rats that live ten-times longer than other rodents and almost never develop cancer because of their abundant production of hyaluronan (HA).33 It is the decreased activity of HA-degrading enzymes (hyaluronidase, nagalase) that results in the unusual cancer resistance observed in naked mole rats.34  To learn how naked mole rats do this naturally, you are urged to read my new book on the topic, which shall be released shortly through NHF.

It is no surprise to learn, then, that GcMAF abolishes cancer not only by activation of the human immune system and stimulation of macrophages that literally digest cancer cells, but by virtue of its ability to inhibit nagalase, an enzyme that degrades connective tissue surrounding tumors. When the integrity of connective tissue is maintained or restored, cancer cells cannot migrate; so, GcMAF stops the spread of cancer (metastasis) and cancer cells die in place.

It is interesting to note that insulin, penicillin, aspirin, and digitalis all came into common use without controlled studies.  In fact, the standard blinded study where half the patients are given an active drug and the other half an ineffective placebo pill and neither patient or doctor know which pill was administered is not ethically acceptable in cancer therapy as half of the tested subjects would be left to die.

Since GcMAF is made in the human body, it is non-toxic. Very few GcMAF-treated patients experience a transient fever as a sluggish immune system is re-awakened. That is about all.

Health regulators will continue to say GcMAF therapy is unproven. Yes, but it is not disproven. It just doesn’t have an official stamp of approval on it. And

________________________

1Ruth Evans, “Investigation over cancer ‘cure’ GcMAF in health food shop,” BBC News, October 16, 2016, at http://www.bbc.com/news/health-37654666.

2Aine McCarthy, “News digest – GcMAF, hijacking immune cells, manipulation of blood vessels and… nose-to-tail eating?,” Cancer Research UK, October 22, 2016, at http://scienceblog.cancerresearchuk.org/2016/10/22/news-digest-gcmaf-hijacking-immune-cells-manipulation-of-blood-vessels-and-nose-to-tail-eating/.

3 Supra, BBC News.

4WorldWideScience.org, at https://worldwidescience.org/topicpages/m/macrophage-activating+factor+gcmaf.html.

5 See https://www.thenhf.com/hfn-magazine/health-freedom-articles/125-2010-articles/2327-29cancer-cured-for-good.

6Gregory KJ, Zhao B, et al., “Vitamin D Binding Protein-Macrophage Activating Factor Directly Inhibits Proliferation, Migration, and uPAR Expression of Prostate Cancer Cells,” PLOS, October 18, 2010, at http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013428.

7EFRANAT, Research & Development, at http://efranat.com/Research-Development1/Canines-Treatment-Results.aspx.

8Bill Sardi, “Is Cancer Being Cured Right Before Our Eyes? Cancer Center In Japan Reports Startling Remissions Using Vitamin & Immunotherapy Regimen,” LewRockwell.com, June 22, 2013, at https://www.lewrockwell.com/2013/06/bill-sardi/is-cancer-being-cured/.

9 See http://www.saisei-mirai.or.jp/gan/macrophage_research_eng.htmlSee also Inui T, Amitani H, et al., “Case Report: A Non-small Cell Lung Cancer Patient Treated with GcMAF, Sonodynamic Therapy and Tumor Treating Fields,” Anticancer Res., 2016 Jul;36(7):3767-70, at https://www.ncbi.nlm.nih.gov/pubmed/27354652; Inui T, Makita K, “Case report: A breast cancer patient treated with GcMAF, sonodynamic therapy and hormone therapy,” Anticancer Res., 2014 Aug;34(8):4589-93, at https://www.ncbi.nlm.nih.gov/pubmed/25075104.

10Inui T, Kuchiike D, et al., “Clinical experience of integrative cancer immunotherapy with GcMAF,” Anticancer Res., 2013 Jul;33(7):2917-9, at https://www.ncbi.nlm.nih.gov/pubmed/23780980.

11Ruggiero M, Ward E, et al., “Oleic Acid, Deglycosylated Vitamin D-Binding Protein, Nitric Oxide: A Molecular Triad Made Lethal to Cancer,” Anticancer Res., 34: 3569-3578 (2014), at http://immunocentre.eu/wp-content/uploads/2014/09/AnticancerResearchClinic.pdf.

12 See, e.g., https://gcmaf.se/videos/.

13 See https://gcmaf.se/wp-content/uploads/2013/06/Gpressnigel.pdf.

14Isobel Dickinson, “Miracle mum: ‘Vampire’ cancer treatment saved my life after I was given months to live,” Daily Star Sunday, April 17, 2016, at http://www.dailystar.co.uk/news/latest-news/508667/gran-Gail-Harling-cured-of-cancer-by-vampire-blood-injection-replacement-treatment.

15Staff writer, “Drug banned in Guernsey amid fears it’s not fit for consumption,” ITV, last updated May 7, 2015, at http://www.itv.com/news/channel/update/2015-02-16/hssd-we-are-looking-for-alternatives-to-gcmaf/.

16Kanda S, Mochizuki Y, et al., “Effects of Vitamin D3-Binding Protein-Derived Macrophage Activating Factor (GcMAF) on Angiogenesis,” J Natl Cancer Inst, (2002) 94 (17): 1311-1319; DOI: https://doi.org/10.1093/jnci/94.17.1311, at https://academic.oup.com/jnci/article/94/17/1311/2519874/Effects-of-Vitamin-D3-Binding-Protein-Derived.

17Staff writer, “Guernsey’s Chief Pharmacist says he has a duty to the public over GcMAF,” ITV, Feb 6, 2017, at http://www.itv.com/news/channel/update/2015-02-06/guernseys-chief-pharmacist-says-he-has-a-duty-to-the-public-over-gcmaf/.

18Staff writer, “Drug banned in Guernsey amid fears it’s not fit for consumption,” ITV, last updated May 7, 2015, at http://www.itv.com/news/channel/update/2015-02-16/hssd-we-are-looking-for-alternatives-to-gcmaf/.

19Morgan G, Ward R, Barton M, “The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies,” See comment in PubMed Commons belowClin Oncol (R Coll Radiol), 2004 Dec;16(8):549-60, at https://www.ncbi.nlm.nih.gov/pubmed/15630849.

20Joe Leogue, “Cancer patients warned to avoid unauthorised ‘miracle cure’,” Irish Examiner, Jan 19, 2016, at http://www.irishexaminer.com/ireland/cancer-patients-warned-to-avoid-unauthorised-miracle-cure-376862.html.

21Tannock IF, Lee CM, et al., “Limited Penetration of Anticancer Drugs through Tumor Tissue,” Clinical Cancer Research, Vol 8, Issue 3 (March 2002), at http://clincancerres.aacrjournals.org/content/8/3/878.full.

22John P. Thomas, “Is The U.S. Medical Mafia Murdering Alternative Health Doctors Who Have Real Cures Not Approved by the FDA?,” Health Impact News, accessed May 12, 2017, at https://healthimpactnews.com/2015/is-the-u-s-medical-mafia-murdering-alternative-health-doctors-who-have-real-cures-not-approved-by-the-fda/.

23 See Chemical & Pharmaceutical Bulletin Feb 1991, at https://www.jstage.jst.go.jp/article/cpb1958/39/2/39_2_505/_pdf.

24Hartmann D, Von Figura G, et al., “Plasma N-acetyl-glucosaminidase in advanced gastro-intestinal adenocarcinoma correlates with age, stage and outcome,” Future Oncol, 2015;11(2):193-203, at https://www.ncbi.nlm.nih.gov/pubmed/25040106.

25Pet Vaccinations Induce Cancerous Growths,” VacTruth, undated, at https://vactruth.com/2012/05/23/pet-vaccinations-cancer/.

26Nguyen DH, Oketch-Rabbah HA, et al., “Radiation Acts on the Microenvironment to Affect Breast Carcinogenesis by Distinct Mechanisms that Decrease Cancer Latency and Affect Tumor Type,” Cancer Cell, Vol 19, Issue 5, p 640-651, 17 May 2011, at http://www.cell.com/cancer-cell/abstract/S1535-6108(11)00121-8.

27Czoka AB & Stern R, “Hypotheses on the evolution of hyaluronan: a highly ironic acid,” Glycobiology, 2013 Apr;23(4):398-411. doi: 10.1093/glycob/cws218. Epub 2013 Jan 12, at https://www.ncbi.nlm.nih.gov/pubmed/23315448.

28Poukka M, Bykachev A, et al., “Decreased expression of hyaluronan synthase 1 and 2 associates with poor prognosis in cutaneous melanoma,” BMC Cancer, 2016 May 16;16:313. doi: 10.1186/s12885-016-2344-8, at https://www.ncbi.nlm.nih.gov/pubmed/27184066.

29Venning FA, Wullkopf L & Erler JT, “Targeting ECM Disrupts Cancer Progression,” Front Oncol, 2015 Oct 20;5:224. doi: 10.3389/fonc.2015.00224. eCollection 2015, at https://www.ncbi.nlm.nih.gov/pubmed/26539408.

30Seino S, et al., “No influence of exogenous hyaluronan on the behavior of human cancer cells or endothelial cell capillary information,” Journal Food Science, July 2014.

31Monslow J, Govindaraju P & Puré E, “Hyaluronan – a functional and structural sweet spot in the tissue microenvironment,” Front Immunol, 2015 May 15;6:231, doi: 10.3389/fimmu.2015.00231. eCollection 2015, at https://www.ncbi.nlm.nih.gov/pubmed/26029216; Wu RL, Huang L, et al., “Hyaluronic acid in digestive cancers,” J Cancer Res Clin Oncol, 2017 Jan;143(1):1-16. doi: 10.1007/s00432-016-2213-5, Epub 2016 Aug 17, at https://www.ncbi.nlm.nih.gov/pubmed/27535565; Tsepilov RN & Beloded AV, “Hyaluronic Acid–an “Old” Molecule with “New” Functions: Biosynthesis and Depolymerization of Hyaluronic Acid in Bacteria and Vertebrate Tissues Including during Carcinogenesis,” Biochemistry (Mosc), 2015 Sep;80(9):1093-108. doi: 10.1134/S0006297915090011, at https://www.ncbi.nlm.nih.gov/pubmed/26555463.

32Turley EA, Wood DK, et al., “Carcinoma Cell Hyaluronan as a “Portable” Cancerized Prometastatic Microenvironment,” See comment in PubMed Commons belowCancer Res, 2016 May 1;76(9):2507-12. doi: 10.1158/0008-5472.CAN-15-3114. Epub 2016 Apr 20, at https://www.ncbi.nlm.nih.gov/pubmed/27197262.

33Fisher GJ, “Cancer resistance, high molecular weight hyaluronic acid, and longevity,” See comment in PubMed Commons belowJ Cell Commun Signal, 2015 Mar;9(1):91-2. doi: 10.1007/s12079-015-0278-6. Epub 2015 Mar 5, at https://www.ncbi.nlm.nih.gov/pubmed/25740467.

34Tian X, Azpurua J, et al., “High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat,” Nature, 2013 Jul 18;499(7458):346-9. doi: 10.1038/nature12234. Epub 2013 Jun 19, at https://www.ncbi.nlm.nih.gov/pubmed/23783513.

35Farkona S, Diamandis EP & Blasutig IM, “Cancer immunotherapy: the beginning of the end of cancer?,” BMC Med, 2016 May 5;14:73. doi: 10.1186/s12916-016-0623-5, at https://www.ncbi.nlm.nih.gov/pubmed/27151159.

36Stephen Matthews, “Revolutionary cancer treatment hailed as a ‘game changer’ could be made more effective for millions of sufferers, scientists say,” Daily Mail, Nov 8, 2016, at: http://www.dailymail.co.uk/health/article-3917434/Revolutionary-cancer-treatment-hailed-game-changer-effective.html#ixzz4gqWblp4r Bolli E, Movahedi K, et al., “Novel insights in the regulation and function of macrophages in the tumor microenvironment,” Curr Opin Oncol, 2017 Jan;29(1):55-61, at https://www.ncbi.nlm.nih.gov/pubmed/27792052.

37Harris SJ, Brown J, et al., “Immuno-oncology combinations: raising the tail of the survival curve,” Cancer Biol Med., 2016 Jun;13(2):171-93. doi: 10.20892/j.issn.2095-3941.2016.0015, at https://www.ncbi.nlm.nih.gov/pubmed/27458526.

38Integrated Healthcare Strategies, Medical Oncology Compensation Survey Report 2013, at http://www.integratedhealthcarestrategies.com/documents/news/77c210ca-4613-4f00-a2e2-b117cb5ff1d5.pdf.

39Thyer L, Ward E, et al., “GC protein-derived macrophage-activating factor decreases α-N-acetylgalactosaminidase levels in advanced cancer patients,” Oncoimmunology, 2013 Aug 1; 2(8): e25769; Published online 2013 Jul 29. doi:  10.4161/onci.25769, at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812199/.

40 See https://gcmaf.se/.

41National Cancer Institute, “Cancer Statistics,” last updated March 22, 2017, at https://www.cancer.gov/about-cancer/understanding/statistics.

42Lizzie Parry, “’The war on cancer may NEVER be won': Cure ‘could be impossible’ because the disease is so highly evolved,” Daily Mail, August 22, 2014, at http://www.dailymail.co.uk/health/article-2731765/The-war-cancer-NEVER-won-Cure-impossible-disease-highly-evolved.html#ixzz4gqMjQtHN.

 

 

[-] Sources and References

The in vitro GcMAF Effects on Endocannabinoid System Transcriptionomics, Receptor Formation, and Cell Activity of Autism-derived Macrophages

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

GC Protein-derived Macrophage-activating Factor Decrease a-N-acetylgalactosamidase Levels in Advanced Cancer Patients

A Novel Role for a Major Component of the Vitamin D Axis: Vitamin D Binding Protein-Derived Macrophage Activating Factor Induces Human Breast Cancer Cell Apoptosis through Stimulation of Macrophages

Vitamin D Binding Protein-macrophage Activating Factor Directly Inhibits Proliferation, Migration, and uPAR Expression of Prostate Cancer Cells

GcMAF: How GcMAF Works

Natural Killer Cells, Miscarriage, and Infertility

Oral Colostrum Macrophage-activating Factor for Serious Infection and Chronic Fatigue Syndrome: Three Case Reports.

GcMAF.se

Marsvenus.com

Norml: Introduction to the Endocannabinoid System

In 2014, researchers in Israel started a small-scale early-stage clinical trial looking at the dosage and safety of GcMAF in cancer patients. The full protocol and further information are available on the Clinicaltrials.gov register[Updated KA 25/07/14]

To sum up

The advent of the internet has led to a wild proliferation of stories of ‘miracle cures’ for cancer – virtually all of which are based on shaky (or zero) science.

Some companies are selling Gc-MAF for use by cancer patients. This treatment is not approved or licensed in the UK for treating cancer or any 0ther disease. Given that there is no solid scientific evidence to show that the treatment is safe or effective, we would not recommend that cancer patients use it. [Updated KA 25/07/14] 

Cancer is an extremely complex disease. In fact, it is more than 200 distinct diseases, each requiring different treatment. And the success of treatment depends on many things, including the genetic make-up of the tumour, the stage of diagnosis, and how aggressive the cancer is.

To suggest that there is a ‘magic bullet’ that cures all cancers is simplistic in the extreme.

Kat

More information and updates:

Anticancer Fund: GcMAF information

Yamamoto’s 2008 paper on Gc-MAF and HIV has also now been retracted by the journal.

The Medicines and Healthcare Regulatory Authority (MHRA) has closed down a factory in Cambridge making Gc-MAF, following concerns about the quality and safety of the products – principally that they were unfit for use in humans. [Updated KA 31/07/15]

[-] Sources and References

The in vitro GcMAF Effects on Endocannabinoid System Transcriptionomics, Receptor Formation, and Cell Activity of Autism-derived Macrophages

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

GC Protein-derived Macrophage-activating Factor Decrease a-N-acetylgalactosamidase Levels in Advanced Cancer Patients

A Novel Role for a Major Component of the Vitamin D Axis: Vitamin D Binding Protein-Derived Macrophage Activating Factor Induces Human Breast Cancer Cell Apoptosis through Stimulation of Macrophages

Vitamin D Binding Protein-macrophage Activating Factor Directly Inhibits Proliferation, Migration, and uPAR Expression of Prostate Cancer Cells

GcMAF: How GcMAF Works

Natural Killer Cells, Miscarriage, and Infertility

Oral Colostrum Macrophage-activating Factor for Serious Infection and Chronic Fatigue Syndrome: Three Case Reports.

GcMAF.se

Marsvenus.com

Norml: Introduction to the Endocannabinoid System

In 2014, researchers in Israel started a small-scale early-stage clinical trial looking at the dosage and safety of GcMAF in cancer patients. The full protocol and further information are available on the Clinicaltrials.gov register[Updated KA 25/07/14]

To sum up

The advent of the internet has led to a wild proliferation of stories of ‘miracle cures’ for cancer – virtually all of which are based on shaky (or zero) science.

Some companies are selling Gc-MAF for use by cancer patients. This treatment is not approved or licensed in the UK for treating cancer or any 0ther disease. Given that there is no solid scientific evidence to show that the treatment is safe or effective, we would not recommend that cancer patients use it. [Updated KA 25/07/14] 

Cancer is an extremely complex disease. In fact, it is more than 200 distinct diseases, each requiring different treatment. And the success of treatment depends on many things, including the genetic make-up of the tumour, the stage of diagnosis, and how aggressive the cancer is.

To suggest that there is a ‘magic bullet’ that cures all cancers is simplistic in the extreme.

Kat

More information and updates:

Anticancer Fund: GcMAF information

Yamamoto’s 2008 paper on Gc-MAF and HIV has also now been retracted by the journal.

The  First Immune clinic in Bussigny, France, offering Gc-MAF treatment has been closed down after several cancer patients died (story is in French).  [Updated KA 31/07/15]

BBC 5Live Investigates: Unlicensed blood drug GcMAF still for sale. [Updated KA 01/10/15 ]

 

 

 

 

 

 

 

Nagalase Blood Test

The Nagalase blood test helps us, at Reno Integrative Medical Center, to identify the activity of an enzyme called Nagalase that helps cancer cells hide from the immune system.

 

What is Nagalase
and why is it so important?

The first thing to understand is that there is one and only one reason cells grow into cancer.  It is a lack of sufficient oxygen to a certain subset of the 210 different types of cells known to make up the human body.  This is called hypoxia.

There may be a thousand things that cause hypoxia, but there is no cancer cell which does not commence and live by hypoxia.

To survive and keep producing energy, these cells must switch over to glycolysis alone as the source of their energy.

At exactly the same time as fermentation starts, the now sickened, dysfunctional cells must also start protecting themselves from the immune system.  They do this by producing a protective enzyme called alpha-N-acetylgalactosaminidase or Nagalase for short.

 

The Nagalase enzyme has the ability to completely shut down the activity of the localized immune macrophage cell, whose job it is to destroy any cell that has been harmed or is not functioning normally.  It effectively “cloaks” the cancer cells from detection by the immune system.  This is the reason that someone can have a strong functioning immune system and still be growing a tumor.  The Nagalase blood test is a good way to check the progress of treatment.

The Nagalase Blood test
exposes the cancer so we can “De-cloak ” it.

A test measuring the level of nagalase in the blood can be used to provide a measure of progress during treatment for cancer.  Remember, the more cancer cells there are, the higher the fermentation process is. This causes the cancer cells to “cloak” or hide their activity from the immune system by producing Nagalase.

There are some other conditions that can cause a false high reading on this test so experience with it is necessary to properly interpret the results.

If a person has had a recent viral infection or if they have recently started a heavy exercise program, it can skew the results.  The reason is that this is exactly what our normal muscle cells do when overworked and the oxygen level falls below a level necessary for respiration.  They will produce the enzyme.

Increase Your T-Cell Army

The way to cut down, or eventually stop, the production of this enzyme is by the use of a compound called Salicinium.  It is a natural plant extract that enters only into cancer cells and reacts in such a way as to shut down the production of nagalase.

When this happens, the macrophage and natural killer cells in the immune system can then recognize the cancer cells as being abnormal and attack and kill them.  We have ways of naturally boosting the immune system and increasing the t-cells so that when the de-cloaking occurs, your body is ready to act.

This is the reason it is so very important to get and keep a strong, balanced immune system even as the treatments are working to kill the abnormal cells.

Our treatments are all designed to stop cancer cells from flourishing.  It is a synergistic collaboration of many factors:

 

From Nagalase blood test back to blood labs

 

 

 

 

 

 

 

GcMAF (or Gc protein-derived macrophage activating factor) is a protein produced by modification of vitamin D-binding protein.[1]

GcMAF has not been properly studied in clinical trials and its laboratory results still need to be confirmed independently. So far, all claims on the efficacy of this product have no solid scientific basis. Its marketing is illegal; therefore there is no controlled guarantee on the quality of the product for human consumption sold over the internet.

Public warning issued by the Anticancer Fund[2]

Biochemically, GcMAF results from sequential deglycosylation of the vitamin D-binding protein (the Gc protein), which is naturally promoted by lymphocytes (B and T cells).[3] The resulting protein may be a macrophage activating factor (MAF).[3] MAFs are lymphokines that control the expression of antigens on the surface of macrophages, and one of their functions is to make macrophages become cytotoxic to tumors.[4]

December 2017 Efranet had obtained an orphan designation from the FDA for use of GcMAF in recurrent respiratory papillomatosis[16] and said that it was conducting a Phase I trial in Israel.[17]

“Vitamin D binding protein macrophage-activating factor”. AdisInsight. Retrieved 7 September 2017.

Bournemouth Echo saying there are over 300 scientific research papers, peer reviewed and published in major scientific journals, 11 of them with her name on them. In fact, GcMAF has 20 beneficial effects in the body.  GcMAF is naturally made in the body by removal of two sugars from Gc-Protein in blood.  This process can be replicated in the laboratory to produce billionths of a gram of GcMAF, which is all you need.

Furthermore, the U.S. Department of Defense actually funded a study of GcMAF, which “shows strong inhibitory activity of GcMAF on prostate tumor cells independent of its macrophage activation.”6 Cancer Research UK is not oblivious to this published science, because for years they’ve had a webpage denigrating GcMAF.

The GcMAF Genie Has Escaped From the Bottle

Despite efforts to quell efforts to commercialize GcMAF as a therapeutic agent for cancer, it has escaped from an attempted stranglehold by health authorities.

A developmental drug company in Israel is proceeding ahead with preliminary human safety studies using GcMAF. The company, EFRANAT, provides a convincing visual picture of the promise posed by GcMAF in photographs of a dog that experienced complete disease-free recovery from T-cell cutaneous lymphoma with GcMAF therapy.  The dog experienced a complete curative effect after only three injectable doses of GcMAF (see below).7

 

Summary of results:  2 of 14 dogs experienced complete recovery; 7 of 14 dogs experienced shrinkage of their tumors and their cancer stabilized and did not spread; 5 of 14 dogs did not respond to treatment.

Moreover, some of these doctors accomplish full recovery of 60% of non-verbal autistic children and were said in news reports to have discovered that vaccines are laced with an enzyme, nagalase (N-acetyl-galactosaminidase) that facilitates the spread of cancer. GcMAF drastically reduces nagalase levels, and treats many vaccine-induced diseases.22

Of considerable interest is the known fact that naked (hairless) mole rats that live ten-times longer than other rodents and almost never develop cancer because of their abundant production of hyaluronan (HA).33 It is the decreased activity of HA-degrading enzymes (hyaluronidase, nagalase) that results in the unusual cancer resistance observed in naked mole rats.34  To learn how naked mole rats do this naturally, you are urged to read my new book on the topic, which shall be released shortly through NHF.

It is no surprise to learn, then, that GcMAF abolishes cancer not only by activation of the human immune system and stimulation of macrophages that literally digest cancer cells, but by virtue of its ability to inhibit nagalase, an enzyme that degrades connective tissue surrounding tumors. When the integrity of connective tissue is maintained or restored, cancer cells cannot migrate; so, GcMAF stops the spread of cancer (metastasis) and cancer cells die in place.

It is interesting to note that insulin, penicillin, aspirin, and digitalis all came into common use without controlled studies.  In fact, the standard blinded study where half the patients are given an active drug and the other half an ineffective placebo pill and neither patient or doctor know which pill was administered is not ethically acceptable in cancer therapy as half of the tested subjects would be left to die.

Since GcMAF is made in the human body, it is non-toxic. Very few GcMAF-treated patients experience a transient fever as a sluggish immune system is re-awakened. That is about all.

Health regulators will continue to say GcMAF therapy is unproven. Yes, but it is not disproven. It just doesn’t have an official stamp of approval on it. And

________________________

1Ruth Evans, “Investigation over cancer ‘cure’ GcMAF in health food shop,” BBC News, October 16, 2016, at http://www.bbc.com/news/health-37654666.

2Aine McCarthy, “News digest – GcMAF, hijacking immune cells, manipulation of blood vessels and… nose-to-tail eating?,” Cancer Research UK, October 22, 2016, at http://scienceblog.cancerresearchuk.org/2016/10/22/news-digest-gcmaf-hijacking-immune-cells-manipulation-of-blood-vessels-and-nose-to-tail-eating/.

3 Supra, BBC News.

4WorldWideScience.org, at https://worldwidescience.org/topicpages/m/macrophage-activating+factor+gcmaf.html.

5 See https://www.thenhf.com/hfn-magazine/health-freedom-articles/125-2010-articles/2327-29cancer-cured-for-good.

6Gregory KJ, Zhao B, et al., “Vitamin D Binding Protein-Macrophage Activating Factor Directly Inhibits Proliferation, Migration, and uPAR Expression of Prostate Cancer Cells,” PLOS, October 18, 2010, at http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013428.

7EFRANAT, Research & Development, at http://efranat.com/Research-Development1/Canines-Treatment-Results.aspx.

8Bill Sardi, “Is Cancer Being Cured Right Before Our Eyes? Cancer Center In Japan Reports Startling Remissions Using Vitamin & Immunotherapy Regimen,” LewRockwell.com, June 22, 2013, at https://www.lewrockwell.com/2013/06/bill-sardi/is-cancer-being-cured/.

9 See http://www.saisei-mirai.or.jp/gan/macrophage_research_eng.htmlSee also Inui T, Amitani H, et al., “Case Report: A Non-small Cell Lung Cancer Patient Treated with GcMAF, Sonodynamic Therapy and Tumor Treating Fields,” Anticancer Res., 2016 Jul;36(7):3767-70, at https://www.ncbi.nlm.nih.gov/pubmed/27354652; Inui T, Makita K, “Case report: A breast cancer patient treated with GcMAF, sonodynamic therapy and hormone therapy,” Anticancer Res., 2014 Aug;34(8):4589-93, at https://www.ncbi.nlm.nih.gov/pubmed/25075104.

10Inui T, Kuchiike D, et al., “Clinical experience of integrative cancer immunotherapy with GcMAF,” Anticancer Res., 2013 Jul;33(7):2917-9, at https://www.ncbi.nlm.nih.gov/pubmed/23780980.

11Ruggiero M, Ward E, et al., “Oleic Acid, Deglycosylated Vitamin D-Binding Protein, Nitric Oxide: A Molecular Triad Made Lethal to Cancer,” Anticancer Res., 34: 3569-3578 (2014), at http://immunocentre.eu/wp-content/uploads/2014/09/AnticancerResearchClinic.pdf.

12 See, e.g., https://gcmaf.se/videos/.

13 See https://gcmaf.se/wp-content/uploads/2013/06/Gpressnigel.pdf.

14Isobel Dickinson, “Miracle mum: ‘Vampire’ cancer treatment saved my life after I was given months to live,” Daily Star Sunday, April 17, 2016, at http://www.dailystar.co.uk/news/latest-news/508667/gran-Gail-Harling-cured-of-cancer-by-vampire-blood-injection-replacement-treatment.

15Staff writer, “Drug banned in Guernsey amid fears it’s not fit for consumption,” ITV, last updated May 7, 2015, at http://www.itv.com/news/channel/update/2015-02-16/hssd-we-are-looking-for-alternatives-to-gcmaf/.

16Kanda S, Mochizuki Y, et al., “Effects of Vitamin D3-Binding Protein-Derived Macrophage Activating Factor (GcMAF) on Angiogenesis,” J Natl Cancer Inst, (2002) 94 (17): 1311-1319; DOI: https://doi.org/10.1093/jnci/94.17.1311, at https://academic.oup.com/jnci/article/94/17/1311/2519874/Effects-of-Vitamin-D3-Binding-Protein-Derived.

17Staff writer, “Guernsey’s Chief Pharmacist says he has a duty to the public over GcMAF,” ITV, Feb 6, 2017, at http://www.itv.com/news/channel/update/2015-02-06/guernseys-chief-pharmacist-says-he-has-a-duty-to-the-public-over-gcmaf/.

18Staff writer, “Drug banned in Guernsey amid fears it’s not fit for consumption,” ITV, last updated May 7, 2015, at http://www.itv.com/news/channel/update/2015-02-16/hssd-we-are-looking-for-alternatives-to-gcmaf/.

19Morgan G, Ward R, Barton M, “The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies,” See comment in PubMed Commons belowClin Oncol (R Coll Radiol), 2004 Dec;16(8):549-60, at https://www.ncbi.nlm.nih.gov/pubmed/15630849.

20Joe Leogue, “Cancer patients warned to avoid unauthorised ‘miracle cure’,” Irish Examiner, Jan 19, 2016, at http://www.irishexaminer.com/ireland/cancer-patients-warned-to-avoid-unauthorised-miracle-cure-376862.html.

21Tannock IF, Lee CM, et al., “Limited Penetration of Anticancer Drugs through Tumor Tissue,” Clinical Cancer Research, Vol 8, Issue 3 (March 2002), at http://clincancerres.aacrjournals.org/content/8/3/878.full.

22John P. Thomas, “Is The U.S. Medical Mafia Murdering Alternative Health Doctors Who Have Real Cures Not Approved by the FDA?,” Health Impact News, accessed May 12, 2017, at https://healthimpactnews.com/2015/is-the-u-s-medical-mafia-murdering-alternative-health-doctors-who-have-real-cures-not-approved-by-the-fda/.

23 See Chemical & Pharmaceutical Bulletin Feb 1991, at https://www.jstage.jst.go.jp/article/cpb1958/39/2/39_2_505/_pdf.

24Hartmann D, Von Figura G, et al., “Plasma N-acetyl-glucosaminidase in advanced gastro-intestinal adenocarcinoma correlates with age, stage and outcome,” Future Oncol, 2015;11(2):193-203, at https://www.ncbi.nlm.nih.gov/pubmed/25040106.

25Pet Vaccinations Induce Cancerous Growths,” VacTruth, undated, at https://vactruth.com/2012/05/23/pet-vaccinations-cancer/.

26Nguyen DH, Oketch-Rabbah HA, et al., “Radiation Acts on the Microenvironment to Affect Breast Carcinogenesis by Distinct Mechanisms that Decrease Cancer Latency and Affect Tumor Type,” Cancer Cell, Vol 19, Issue 5, p 640-651, 17 May 2011, at http://www.cell.com/cancer-cell/abstract/S1535-6108(11)00121-8.

27Czoka AB & Stern R, “Hypotheses on the evolution of hyaluronan: a highly ironic acid,” Glycobiology, 2013 Apr;23(4):398-411. doi: 10.1093/glycob/cws218. Epub 2013 Jan 12, at https://www.ncbi.nlm.nih.gov/pubmed/23315448.

28Poukka M, Bykachev A, et al., “Decreased expression of hyaluronan synthase 1 and 2 associates with poor prognosis in cutaneous melanoma,” BMC Cancer, 2016 May 16;16:313. doi: 10.1186/s12885-016-2344-8, at https://www.ncbi.nlm.nih.gov/pubmed/27184066.

29Venning FA, Wullkopf L & Erler JT, “Targeting ECM Disrupts Cancer Progression,” Front Oncol, 2015 Oct 20;5:224. doi: 10.3389/fonc.2015.00224. eCollection 2015, at https://www.ncbi.nlm.nih.gov/pubmed/26539408.

30Seino S, et al., “No influence of exogenous hyaluronan on the behavior of human cancer cells or endothelial cell capillary information,” Journal Food Science, July 2014.

31Monslow J, Govindaraju P & Puré E, “Hyaluronan – a functional and structural sweet spot in the tissue microenvironment,” Front Immunol, 2015 May 15;6:231, doi: 10.3389/fimmu.2015.00231. eCollection 2015, at https://www.ncbi.nlm.nih.gov/pubmed/26029216; Wu RL, Huang L, et al., “Hyaluronic acid in digestive cancers,” J Cancer Res Clin Oncol, 2017 Jan;143(1):1-16. doi: 10.1007/s00432-016-2213-5, Epub 2016 Aug 17, at https://www.ncbi.nlm.nih.gov/pubmed/27535565; Tsepilov RN & Beloded AV, “Hyaluronic Acid–an “Old” Molecule with “New” Functions: Biosynthesis and Depolymerization of Hyaluronic Acid in Bacteria and Vertebrate Tissues Including during Carcinogenesis,” Biochemistry (Mosc), 2015 Sep;80(9):1093-108. doi: 10.1134/S0006297915090011, at https://www.ncbi.nlm.nih.gov/pubmed/26555463.

32Turley EA, Wood DK, et al., “Carcinoma Cell Hyaluronan as a “Portable” Cancerized Prometastatic Microenvironment,” See comment in PubMed Commons belowCancer Res, 2016 May 1;76(9):2507-12. doi: 10.1158/0008-5472.CAN-15-3114. Epub 2016 Apr 20, at https://www.ncbi.nlm.nih.gov/pubmed/27197262.

33Fisher GJ, “Cancer resistance, high molecular weight hyaluronic acid, and longevity,” See comment in PubMed Commons belowJ Cell Commun Signal, 2015 Mar;9(1):91-2. doi: 10.1007/s12079-015-0278-6. Epub 2015 Mar 5, at https://www.ncbi.nlm.nih.gov/pubmed/25740467.

34Tian X, Azpurua J, et al., “High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat,” Nature, 2013 Jul 18;499(7458):346-9. doi: 10.1038/nature12234. Epub 2013 Jun 19, at https://www.ncbi.nlm.nih.gov/pubmed/23783513.

35Farkona S, Diamandis EP & Blasutig IM, “Cancer immunotherapy: the beginning of the end of cancer?,” BMC Med, 2016 May 5;14:73. doi: 10.1186/s12916-016-0623-5, at https://www.ncbi.nlm.nih.gov/pubmed/27151159.

36Stephen Matthews, “Revolutionary cancer treatment hailed as a ‘game changer’ could be made more effective for millions of sufferers, scientists say,” Daily Mail, Nov 8, 2016, at: http://www.dailymail.co.uk/health/article-3917434/Revolutionary-cancer-treatment-hailed-game-changer-effective.html#ixzz4gqWblp4r Bolli E, Movahedi K, et al., “Novel insights in the regulation and function of macrophages in the tumor microenvironment,” Curr Opin Oncol, 2017 Jan;29(1):55-61, at https://www.ncbi.nlm.nih.gov/pubmed/27792052.

37Harris SJ, Brown J, et al., “Immuno-oncology combinations: raising the tail of the survival curve,” Cancer Biol Med., 2016 Jun;13(2):171-93. doi: 10.20892/j.issn.2095-3941.2016.0015, at https://www.ncbi.nlm.nih.gov/pubmed/27458526.

38Integrated Healthcare Strategies, Medical Oncology Compensation Survey Report 2013, at http://www.integratedhealthcarestrategies.com/documents/news/77c210ca-4613-4f00-a2e2-b117cb5ff1d5.pdf.

39Thyer L, Ward E, et al., “GC protein-derived macrophage-activating factor decreases α-N-acetylgalactosaminidase levels in advanced cancer patients,” Oncoimmunology, 2013 Aug 1; 2(8): e25769; Published online 2013 Jul 29. doi:  10.4161/onci.25769, at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812199/.

40 See https://gcmaf.se/.

41National Cancer Institute, “Cancer Statistics,” last updated March 22, 2017, at https://www.cancer.gov/about-cancer/understanding/statistics.

42Lizzie Parry, “’The war on cancer may NEVER be won': Cure ‘could be impossible’ because the disease is so highly evolved,” Daily Mail, August 22, 2014, at http://www.dailymail.co.uk/health/article-2731765/The-war-cancer-NEVER-won-Cure-impossible-disease-highly-evolved.html#ixzz4gqMjQtHN.

 

 

[-] Sources and References

The in vitro GcMAF Effects on Endocannabinoid System Transcriptionomics, Receptor Formation, and Cell Activity of Autism-derived Macrophages

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

GC Protein-derived Macrophage-activating Factor Decrease a-N-acetylgalactosamidase Levels in Advanced Cancer Patients

A Novel Role for a Major Component of the Vitamin D Axis: Vitamin D Binding Protein-Derived Macrophage Activating Factor Induces Human Breast Cancer Cell Apoptosis through Stimulation of Macrophages

Vitamin D Binding Protein-macrophage Activating Factor Directly Inhibits Proliferation, Migration, and uPAR Expression of Prostate Cancer Cells

GcMAF: How GcMAF Works

Natural Killer Cells, Miscarriage, and Infertility

Oral Colostrum Macrophage-activating Factor for Serious Infection and Chronic Fatigue Syndrome: Three Case Reports.

GcMAF.se

Marsvenus.com

Norml: Introduction to the Endocannabinoid System

In 2014, researchers in Israel started a small-scale early-stage clinical trial looking at the dosage and safety of GcMAF in cancer patients. The full protocol and further information are available on the Clinicaltrials.gov register[Updated KA 25/07/14]

To sum up

The advent of the internet has led to a wild proliferation of stories of ‘miracle cures’ for cancer – virtually all of which are based on shaky (or zero) science.

Some companies are selling Gc-MAF for use by cancer patients. This treatment is not approved or licensed in the UK for treating cancer or any 0ther disease. Given that there is no solid scientific evidence to show that the treatment is safe or effective, we would not recommend that cancer patients use it. [Updated KA 25/07/14] 

Cancer is an extremely complex disease. In fact, it is more than 200 distinct diseases, each requiring different treatment. And the success of treatment depends on many things, including the genetic make-up of the tumour, the stage of diagnosis, and how aggressive the cancer is.

To suggest that there is a ‘magic bullet’ that cures all cancers is simplistic in the extreme.

Kat

More information and updates:

Anticancer Fund: GcMAF information

Yamamoto’s 2008 paper on Gc-MAF and HIV has also now been retracted by the journal.

The Medicines and Healthcare Regulatory Authority (MHRA) has closed down a factory in Cambridge making Gc-MAF, following concerns about the quality and safety of the products – principally that they were unfit for use in humans. [Updated KA 31/07/15]

[-] Sources and References

The in vitro GcMAF Effects on Endocannabinoid System Transcriptionomics, Receptor Formation, and Cell Activity of Autism-derived Macrophages

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

GC Protein-derived Macrophage-activating Factor Decrease a-N-acetylgalactosamidase Levels in Advanced Cancer Patients

A Novel Role for a Major Component of the Vitamin D Axis: Vitamin D Binding Protein-Derived Macrophage Activating Factor Induces Human Breast Cancer Cell Apoptosis through Stimulation of Macrophages

Vitamin D Binding Protein-macrophage Activating Factor Directly Inhibits Proliferation, Migration, and uPAR Expression of Prostate Cancer Cells

GcMAF: How GcMAF Works

Natural Killer Cells, Miscarriage, and Infertility

Oral Colostrum Macrophage-activating Factor for Serious Infection and Chronic Fatigue Syndrome: Three Case Reports.

GcMAF.se

Marsvenus.com

Norml: Introduction to the Endocannabinoid System

In 2014, researchers in Israel started a small-scale early-stage clinical trial looking at the dosage and safety of GcMAF in cancer patients. The full protocol and further information are available on the Clinicaltrials.gov register[Updated KA 25/07/14]

To sum up

 

 

Notice

GcMAF

From Wikipedia, the free encyclopedia

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GcMAF (or Gc protein-derived macrophage activating factor) is a protein produced by modification of vitamin D-binding protein.[1]

GcMAF has not been properly studied in clinical trials and its laboratory results still need to be confirmed independently. So far, all claims on the efficacy of this product have no solid scientific basis. Its marketing is illegal; therefore there is no controlled guarantee on the quality of the product for human consumption sold over the internet.

Public warning issued by the Anticancer Fund[2]

Biochemically, GcMAF results from sequential deglycosylation of the vitamin D-binding protein (the Gc protein), which is naturally promoted by lymphocytes (B and T cells).[3] The resulting protein may be a macrophage activating factor (MAF).[3] MAFs are lymphokines that control the expression of antigens on the surface of macrophages, and one of their functions is to make macrophages become cytotoxic to tumors.[4]

Contents

1

False cancer-curing claims

2

See also

3

References

4

Further readingFalse cancer-curing claims[edit]

Starting around 2008, GcMAF has been promoted as a cure for cancer,[5] HIV,[6] autism[7] and other conditions.[8]

Three out of four of the original studies authored by Yamamoto (published between 2007 and 2009) were retracted by the scientific journals in which they were published in 2014, officially due to irregularities in the way ethical approval was granted.[6][9][10][11] Retraction reasons also included methodological errors in the studies.[12][13] The integrity of the research, conducted by Nobuto Yamamoto and colleagues, that originally prompted claims regarding cancer and HIV has been questioned.[5][2]

The UK Medicines and Healthcare products Regulatory Agency[8] and Cancer Research UK has warned the public about spurious claims of clinical benefits, misleadingly based on reduced levels of the alpha-N-acetylgalactosaminidase enzyme (also known as nagalase), whose production might be increased in many cancers.[5]

In 2014 the Belgian Anticancer Fund has communicated serious concerns about published studies on GcMAF by Yamamoto and colleagues.[2]

In 2015 the UK Medicines and Healthcare products Regulatory Agency (MHRA) closed a factory in Milton, Cambridgeshire owned by David Noakes‘ company Immuno Biotech manufacturing GcMAF for cancer treatment.[14] In September 2018 Noakes pleaded guilty to manufacturing a medicinal product without a manufacturer’s licence, selling or supplying medicinal products without market authorisation, and money laundering.[15]

As of 2014 an Israeli company called Efranat was running a clinical trial of GcMAF in people with various kinds of cancer at a hospital in Israel.[16] As of December 2017 Efranet had obtained an orphan designation from the FDA for use of GcMAF in recurrent respiratory papillomatosis[17] and said that it was conducting a Phase I trial in Israel.[18]

See also[edit]

List of ineffective cancer treatments

References[edit]

1 Jump up
^
Galactosidases — Advances in Research and Application. Scholarly Editions. 21 June 2013. p. 52. ISBN 978-1-4816-8801-7.

2^ Jump up to:
a b c “GCMAF”. Anticancer Fund. 24 July 2014. Retrieved 2014-07-26.

3^ Jump up to:
a b Malik, Suneil; Fu, Lei; Juras, David James; Karmali, Mohamed; Wong, Betty Y. L.; Gozdzik, Agnes; Cole, David E. C. (January–February 2013). “Common variants of the vitamin D binding protein gene and adverse health outcomes”. Critical Reviews in Clinical Laboratory Sciences. 50 (1): 1–22. doi:10.3109/10408363.2012.750262. PMC 3613945. PMID 23427793.

4 Jump up
^
Mosser, David M. (February 2003). “The many faces of macrophage activation”. Journal of Leukocyte Biology. 73 (2): 209–212. doi:10.1189/jlb.0602325. PMID 12554797.

5^ Jump up to:
a b c Arney, Kat (3 December 2008). “‘Cancer cured for good?’ – Gc-MAF and the miracle cure (revised 25 July 2014)”. Cancer Research UK. Retrieved 10 February 2015.

6^ Jump up to:
a b (Retracted) Yamamoto, Nobuto; Ushijima, Naofumi; Koga, Yoshihiko (January 2009). “Immunotherapy of HIV-infected patients with Gc protein-derived macrophage activating factor (GcMAF)”. Journal of Medical Virology. 81 (1): 16–26. doi:10.1002/jmv.21376. PMID 19031451.

7 Jump up
^
Miller, Michael E. (16 July 2015). “The mysterious death of a doctor who peddled autism ‘cures’ to thousands”. Washington Post. Retrieved 26 August 2015.

8^ Jump up to:
a b “Press Release: Regulator warns against GcMAF made in unlicensed facility in Cambridgeshire – GOV.UK”. Medicines and Healthcare products Regulatory Agency. 3 February 2015.

9 Jump up
^
(Retracted) Yamamoto, Nobuto; Suyama, Hirofumi; Yamamoto, Nobuyuki; Ushijima, Naofumi (15 January 2008). “Immunotherapy of metastatic breast cancer patients with vitamin D-binding protein-derived macrophage activating factor (GcMAF)”. International Journal of Cancer. 122 (2): 461–467. doi:10.1002/ijc.23107.

10 Jump up
^
Yamamoto, N.; Suyama, H.; Nakazato, H.; Yamamoto, N.; Koga, Y. (2014). “Retraction Note to: Immunotherapy of metastatic colorectal cancer with vitamin D-binding protein-derived macrophage-activating factor, GcMAF”. Cancer Immunology, Immunotherapy. 63 (12): 1349. doi:10.1007/s00262-014-1616-x.

11 Jump up
^
“Retraction”. International Journal of Cancer. 135 (6): 1509. 15 September 2014. doi:10.1002/ijc.29014.

12 Jump up
^
Ivan Oransky (25 July 2014). “Paper about widely touted but unapproved “cure” for cancer, autism retracted”. Retractionwatch.

13 Jump up
^
“Tracking retractions as a window into the scientific process Yet another study of widely touted cancer “cure” retracted”. Retraction Watch. Retraction Watch. Retrieved 28 July 2015.

14 Jump up
^
UK’s MHRA shuts down GcMAF plant (FDA News website)

15 Jump up
^
Mann, Nick. “Man behind GcMAF is facing jail”. Retrieved 2018-09-30.

16 Jump up
^
Cancer treatment developer Efranat raises $4.5 million, November 18, 2014 (Globes)

17 Jump up
^
“Orphan Drug Designation – Modified vitamin D binding protein”. FDA. Retrieved 13 December 2017.

18 Jump up
^
“Vitamin D binding protein macrophage-activating factor”. AdisInsight. Retrieved 7 September 2017.

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