Beta Glucan is a well known stimulator of white blood cell maturation and activity. (27) β-(1,3/1,6)-d-glucan boosted dendritic cells (DCs) maturation, and cytotoxic T lymphocyte responses. (28)Bitter Melon has shown multiple actions against Pancreatic cancer cells. (19) It can overcome Cisplatin resistance in Ovarian Cancer cells by exerting anticancer effects through activation of AMPK and suppression of mTOR. (20)
Boswellia inhibits NF-kB and 5-LOX, initiators of inflammation, and increases apoptosis. (23) Boswellia increased the cytotoxicity of doxorubicin and cisplatin in Triple Negative Breast Cancer cells. (24)
Curcumin upregulates tumor suppressing genes. (1) Curcumin inhibits the growth factors cancers cells use to proliferate and suppresses the growth of cancer stem cells. (2) In human breast, esophageal, and colon cancer, curcumin increased the malignant cells’ sensitivity to chemotherapy drugs and to the effects of radiation treatments. (3).
Flaxseed Lignans reduce growth and metastasis in breast cancer. (31)
Green Tea contains a polyphenol called EGCG, which has been shown to suppress tumor growth by blocking the growth of new blood vessels to supply the tumor. (4) Studies show that EGCG suppresses the growth and invasion of human breast cancer cells. (5) Green Tea also increased apoptosis, or programmed cell death, in cancer cells. (6)
Maitake mushroom and its polysaccharides boosts the activity of white blood cells. (11) Clinical studies show systemic anti-tumor immune response. (12)
Mangosteen Fruit Rind contains a-Mangostin, which has been shown to inhibit cell growth in many cancers. (21) Mangosteen was shown to inhibit growth and induce apoptosis of breast cancer cells. (22)
Milk Thistle has shown an ability to prevent UVB-induced skin cancers. (25) Milk Thistle component Silymarin suppressed cell growth and arrested cell cycle progression in Ovarian Cancer. (26)
Pterostilbene selectively kills breast cancer stem cells. (32)
Quercetin exerts anti-tumor activity through multiple pathways. (15) Quercetin has shown synergistic effects when combined with chemotherapeutic agents or radiotherapy, while at the same time protecting healthy cells from the damage of such treatments, in a variety of cancers. (16)
Reishi mushroom has been shown to boost apoptosis through the Caspase pathway. (13) It was also shown to reduce tumor growth and rate in Inflammatory Breast Cancer in human trials. (14)
Se-Methylselenocysteine, the natural form of Selenium found in vegetables, inhibits growth of prostate cancer. (33)
Turkey Tail (Trametes versicolor) mushroom has over 20 clinical studies that show it reduces tumor growth. (9) In a phase I clinical study of women with breast cancer, it was shown to increase Natural Killer Cell activity, the immune cells that target cancer. (10) Bastyr Naturopathic University’s cancer research department received a large grant to better study this mushroom. With reishi (gonaderma), boletus and, among others, the infamous “champignon de Paris”, turkey tail fungi should be a “forget-me-not”.
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