Integrative Oncology Protocols

With integrative oncology, there are many protocols. In the United States, all licensed oncologists need to practice the conventional standards of care, therefore, radiation, surgery, chemo and targeted drug therapies are required. These oncologists will therefore use holistic methods to mitigated both the cancer and especially the conventional treatment, as allopathic medicine is laden with toxic consequences that harm the body.

However,  unlike with conventional oncology, most integrative oncologists will not use the  “one size fits all” model. What works for one patient’s cancer may not work for the next, if only because every cancer is genetically unique and its cells are constantly changing.

In this perspective, since most integrative oncologists use chemo, albeit diluted, they usually recommend genetic testing. To to prescription, when indicated, they will try immunotherapeutics (See blog) to stimulate the innate immune system. Some of the more holistic integrative oncologists will use Coley’s “vaccine”  (ie toxins consists of heat-killed bacteria that stimulate the innate immune system to attack abnormal cells) and GcMAF (i.e.  a macrophage activating factor that is normally inhibited by cancer cells). To which can be added Interleukin-2  (ie  a substance produced by the body that stimulates production of cytotoxic T cells, which can kill cancer cells).

Exceptionally, a few integrative oncologists will use one of the main standards holistic oncologist use, which is whole body hyperthermia. This technique is a process where the patient is warmed to a temperature of up to 104 or more degrees Fahrenheit. Increased temperature stimulates increased innate immune function.

To target the cancer’s energy requirements, integrative oncologists will use glycolytic inhibitors like metformin and DCA,  (dichloroacetate), both of which inhibit the cancer cells’ ability to utilize sugar, while promoting normal mitochondrial oxidative phosphorylation (cancer cells that use oxidative phosphorylation are more susceptible to being destroyed).

Next dose doxycycline will usually be recommended, as this enzyme inhibits  the matrix metalloproteinase. Cancer cells dig into this matrix by secreting an enzyme that breaks down tissue. Low inhibits release of this enzyme.

Angiogenesis inhibitors are normally promoted in order to stop or slow down the growth of new cancer vessels. Both conventional ones like avastin or more experimental and natural ones coming from food and other molecules are used. Tumors can not grow without sprouting new vessels. Vessel formation is dependent on adequate amounts of copper. Thus,  if copper is depleted, tumors can’t grow well.  Ammonium tetrathiomolybdate chelates copper, thereby inhibiting angiogenesis and there are a few integrative oncologists who use this technique.

Most integrative oncologists will use  vitamin C, at high doses intravenously. And some will combine this vitamin with vitamin K3 at a ratio of 100:1. This combo is preferentially cytotoxic to cancer cells, while leaving normal cells unharmed.

For mitosis inhibitors,  most American integrative oncologists will use conventional techniques. Cancer cells divide rapidly through a process called mitosis. Mitosis occurs through a process known as spindle formation. During spindle formation, spindles pull the chromosomes to opposite sides of the cell, in preparation for cell division. IPT (insuline potentiation therapy) is usually the preferred mitosis inhibitor. This technique consists in using a diluted conventional chemo, around 10 percent, mixed with glucose and preceded with an insulin shot. This way, most of the chemo will be absorbed in the cancer and not  by healthy cells. Noscapine, an opioid agonist binds to the spindles, can also inhibit mitosis and a few integrative oncologists use this.

Research has shown that several cancers, including breast, cervical, uterine, lung, and colorectal, often fuel their growth through the production of estrogen. Aromatase inhibitors block production of estrogen. Thus, these are also used. IGF-1; IGF-1, or insulin-like growth factor-1 is a growth factor that often fuels cancer growth. Octreotide inhibits the production of IGF-1, so this molecule is used while most holistic oncologists will prefer a more metabolic nutritional approach.

GnRh agonists; GnRh agonists, or gonadotropin releasing hormone agonists may inhibit cancer in 2 ways. GnRh inhibits production of the sex steroids; if the cancer is dependent on sex steroids, GnRh will slow cancer growth. In addition, many cancers have receptors for GnRh, which when stimulated, inhibit cancer growth. Many other drugs and natural supplements are often used as well, depending on the specifics of the patients’ cancer.

Using this combination of conventional and alternative therapies,  many pathways of cancer growth can indeed be but off, thus converting an acutely progressive disease, into a stable, chronic disease.

On the other hand, holistic oncologists will prefer less invasive and more natural methods so as to avoid recurrence and the chronic aspect of the disease.


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